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  1. Esophageal cancer is one of the most aggressive malignancies, and is associated with multiple genetic mutations. At present, the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) gene mutation has been obs...

    Authors: Aihemaijiang Kuerbanjiang, Maimaitiyiming Maimaituerxun, Yanjun Zhang, Yiliang Li, Gang Cui, Aibaidula Abuduhabaier, Abuduwaili Aierken, Buya Miranbieke, Meilikezati Anzaer and Yusufu Maimaiti

    Citation: BMC Gastroenterology 2021 21:86

    Content type: Research article

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  2. Transanal endorectal pull-through (TEPT) is considered the most preferable treatment method for Hirschsprung disease (HSCR) since it is less invasive and has fewer morbidities than transabdominal pull-through....

    Authors: Gunadi, Gabriele Ivana, Desyifa Annisa Mursalin, Ririd Tri Pitaka, Muhammad Wildan Zain, Dyah Ayu Puspitarani, Dwiki Afandy, Susan Simanjaya, Andi Dwihantoro and Akhmad Makhmudi

    Citation: BMC Gastroenterology 2021 21:85

    Content type: Research article

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  3. Hepatic cavernous hemangioma is the most common type of benign liver tumor. Although ruptures and hemorrhages of hepatic hemangioma are rare complications, they are associated with high mortality. Most practit...

    Authors: Yong-Guang Yang, Wei-Feng Chen, Wei-Heng Mai, Xiao-Fang Li, Hong-Lian Zhou, Li-Juan Liu and Ming-Yi Li

    Citation: BMC Gastroenterology 2021 21:84

    Content type: Case report

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  4. The application of measurement instruments is a strategy to evaluate the patient's knowledge about the disease. This study aims to build an instrument that evaluates the patient's knowledge about liver cirrhosis.

    Authors: Mariana Stelmach, Kayo Augusto de Almeida Medeiros, Bárbara Justo Carvalho, Leonardo Zumerkorn Pipek, Gustavo Heluani Antunes de Mesquita, Fernanda Nii, Diego Ramos Martines, Leandro Ryuchi Iuamoto, Luiz Augusto Carneiro D’Albuquerque, Alberto Meyer and Wellington Andraus

    Citation: BMC Gastroenterology 2021 21:83

    Content type: Research article

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  5. Despite the growing body of knowledge about TM6SF2 and PNPLA3 polymorphisms in non-alcoholic fatty liver disease, their influence in the spectrum of HCV liver disease is not yet fully defined. Besides that, ad...

    Authors: Arthur Ivan N. Oliveira, Fernanda M. Malta, Patricia Momoyo Y. Zitelli, Ana Paula M. Salles, Michele S. Gomes-Gouvea, Ana Catharina S. Nastri, Joao Renato R. Pinho, Flair J. Carrilho, Claudia P. Oliveira, Maria Cássia Mendes-Corrêa, Mario G. Pessoa and Daniel F. Mazo

    Citation: BMC Gastroenterology 2021 21:81

    Content type: Research article

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  6. Risk indices such as the pancreas donor risk index (PDRI) and pre-procurement pancreas allocation suitability score (P-PASS) are utilised in solid pancreas transplantation however no review has compared all de...

    Authors: Jonathan E. H. Ling, Timothy Coughlan, Kevan R. Polkinghorne and John Kanellis

    Citation: BMC Gastroenterology 2021 21:80

    Content type: Research article

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  7. Functional dyspepsia (FD) is often comorbid with sleep disturbance. However, it is not fully understood how sleep disturbance affects the pathophysiology of FD. We aimed to investigate the relationship between...

    Authors: Fumihiko Nakamura, Shiko Kuribayashi, Fumio Tanaka, Noriyuki Kawami, Yasuhiro Fujiwara, Katsuhiko Iwakiri, Motoyasu Kusano and Toshio Uraoka

    Citation: BMC Gastroenterology 2021 21:78

    Content type: Research article

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  8. The threshold concentration of infliximab during maintenance therapy has not been well-defined in relation to histologic remission. The aim of the study is to dentify the maintenance-phase infliximab concentra...

    Authors: Aze Wilson, Bethany Choi, Michael Sey, Terry Ponich, Melanie Beaton and Richard B. Kim

    Citation: BMC Gastroenterology 2021 21:77

    Content type: Research article

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  9. Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania.

    Authors: Edite Sadiku, Eqerem Hasani, Indrit Këlliçi, Iris Mone, Fatjona Kraja, Bledar Kraja and Genc Burazeri

    Citation: BMC Gastroenterology 2021 21:76

    Content type: Research article

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  10. Crohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables observation of the whole GI tract, but its diagnost...

    Authors: Keisaku Yamada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Eri Ishikawa, Takuya Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Eizaburo Ohno, Hiroki Kawashima, Takashi Honda, Masatoshi Ishigami and Mitsuhiro Fujishiro

    Citation: BMC Gastroenterology 2021 21:75

    Content type: Research article

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  11. When performing colorectal endoscopic submucosal dissection (ESD) in obese patients, technically difficult cases are sometimes experienced because of difficulty with the insertion of the colonoscope, poor scop...

    Authors: Jun Tachikawa, Hideyuki Chiba, Naoya Okada, Jun Arimoto, Keiichi Ashikari, Hiroki Kuwabara, Michiko Nakaoka, Takuma Higurashi, Toru Goto and Atsushi Nakajima

    Citation: BMC Gastroenterology 2021 21:74

    Content type: Research article

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  12. The pathological conditions of UC and CD involved in inflammatory bowel disease-unclassified (IBD-U), UC with primary sclerosing cholangitis (PSC-UC), and UC with autoimmune pancreatitis type 2 (AIP-UC) remain...

    Authors: Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2021 21:73

    Content type: Research article

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  13. Anastomotic leakage (AL) in the upper gastrointestinal (GI) tract is associated with high morbidity and mortality rates. Especially intrathoracic anastomotic leakage leads to life-threatening complications. En...

    Authors: Chengcheng Christine Zhang, Lukas Liesenfeld, Rosa Klotz, Ronald Koschny, Christian Rupp, Thomas Schmidt, Markus K. Diener, Beat P. Müller-Stich, Thilo Hackert, Peter Sauer, Markus W. Büchler and Anja Schaible

    Citation: BMC Gastroenterology 2021 21:72

    Content type: Research article

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  14. Inflammatory bowel disease (IBD) is increasing in the Asia-Pacific region, with changes in disease phenotype and course. We aimed to assess the changing phenotypes of IBD over ten years, describe the early cli...

    Authors: M. A. Niriella, I. K. Liyanage, S. K. Kodisinghe, A. P. De Silva, A. V. G. A. M. Jayatissa, N. M. M. Navarathne, R. K. Peiris, U. P. Kalubovila, S. R. Kumarasena, R. W. Jayasekara and H. J. de Silva

    Citation: BMC Gastroenterology 2021 21:71

    Content type: Research article

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  15. NER1006 (Plenvu®, Salix Pharmaceuticals, Bridgewater, NJ) is a 1 L polyethylene glycol bowel preparation indicated for colonoscopy in adults. A US online survey assessed real-world ease of use and treatment satis...

    Authors: Brooks D. Cash, Mary Beth C. Moncrief, Michael S. Epstein and David M. Poppers

    Citation: BMC Gastroenterology 2021 21:70

    Content type: Research article

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  16. Positron emission tomography (PET) has the potential for visualization and quantification of gastric emptying (GE). The traditional Chinese medicine (TCM) has been recognized promising for constipation. This s...

    Authors: Xueyan Chen, Yu Liu, Donghui Pan, Maoyu Cao, Xinyu Wang, Lizhen Wang, Yuping Xu, Yan Wang, Junjie Yan, Juan Liu and Min Yang

    Citation: BMC Gastroenterology 2021 21:69

    Content type: Research article

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  17. Liver cancer is one of the most common malignancies worldwide. HCC (hepatocellular carcinoma) is the predominant pathological type of liver cancer, accounting for approximately 75–85 % of all liver cancers. Li...

    Authors: Wenjie Wang, Chen Zhang, Qihong Yu, Xichuan Zheng, Chuanzheng Yin, Xueke Yan, Gang Liu and Zifang Song

    Citation: BMC Gastroenterology 2021 21:68

    Content type: Research article

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  18. Testicular cancer (TC) survivors have an increased risk of various second primary malignancies. A recent cohort study detected an increased risk of colorectal cancer (CRC) in TC survivors treated with platinum...

    Authors: Berbel L. M. Ykema, Tanya M. Bisseling, Manon C. W. Spaander, Leon M. G. Moons, Dorien van der Biessen-van Beek, Lisette Saveur, Martijn Kerst, Sasja F. Mulder, Ronald de Wit, Danielle Zweers, Gerrit A. Meijer, Jos H. Beijnen, Iris Lansdorp-Vogelaar, Flora E. van Leeuwen, Petur Snaebjornsson and Monique E. van Leerdam

    Citation: BMC Gastroenterology 2021 21:67

    Content type: Study protocol

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  19. Amyloid deposition in pancreas is rare. Lactoferrin amyloid deposition has not been reported in pancreas, till date. Presence of enhancing mural nodule in a cyst on imaging is a worrisome feature for malignanc...

    Authors: Katherine A. Baugh, Svetang Desai, George Van Buren 2nd, William E. Fisher, Carlos A. Farinas and Sadhna Dhingra

    Citation: BMC Gastroenterology 2021 21:66

    Content type: Case report

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  20. Single nucleotide polymorphism (SNP)-based polygenic risk scoring is predictive of colorectal cancer (CRC) risk. However, few studies have investigated the association of genetic risk score (GRS) with detectio...

    Authors: Michael J. Northcutt, Zhuqing Shi, Michael Zijlstra, Ayush Shah, Siqun Zheng, Eugene F. Yen, Omar Khan, Mohammad Imran Beig, Polina Imas, Adam Vanderloo, Obaid Ansari, Jianfeng Xu and Jay L. Goldstein

    Citation: BMC Gastroenterology 2021 21:65

    Content type: Research article

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  21. Endoscopic submucosal dissection (ESD) and endoscopic submucosal excavation (ESE) have been widely used and have gradually become the main endoscopic treatment for gastrointestinal mucosal and submucosal lesio...

    Authors: Yongkang Lai, Qian Zhang, Xiaolin Pan, Zhenhua Zhu, Shunhua Long, Xiaojiang Zhou, Guohua Li, Yin Zhu, Youxiang Chen and Xu Shu

    Citation: BMC Gastroenterology 2021 21:64

    Content type: Research article

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  22. Methods have been developed for preventing delayed bleeding (DB) after gastric endoscopic submucosal dissection (GESD). However, none of the methods can completely prevent DB. We hypothesized that DB could be ...

    Authors: Satoshi Abiko, Soichiro Oda, Akimitsu Meno, Akane Shido, Sonoe Yoshida, Ayumu Yoshikawa, Kazuaki Harada, Naoki Kawagishi, Itsuki Sano, Hisashi Oda and Takuto Miyagishima

    Citation: BMC Gastroenterology 2021 21:63

    Content type: Research article

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  23. Cholecystectomy (XGB) is the most common abdominal surgery performed in the United States and is associated with an increased post-surgery incidence of metabolic and gastrointestinal (GI) diseases. Two main ri...

    Authors: Celeste Alexander, Tzu-Wen L. Cross, Anne H. Lee, Lindsey K. Ly, Miranda D. Vieson, Jason M. Ridlon, Erik R. Nelson and Kelly S. Swanson

    Citation: BMC Gastroenterology 2021 21:62

    Content type: Research article

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  24. Laparoscopic splenectomy (LS) being used after Transjugular intrahepatic portosystemic shunt (TIPS) has not been reported. This report aims to explore the feasibility, safety, and potential efficacy of LS afte...

    Authors: Yingying Li, Zuojin Liu and Chang’an Liu

    Citation: BMC Gastroenterology 2021 21:61

    Content type: Research article

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  25. Constitutional mismatch repair deficiency (CMMRD) is caused by biallelic pathogenic variants in one of the mismatch repair genes, and results in early onset colorectal cancer, leukemia, brain tumors and other ...

    Authors: Keinosuke Hizuka, Shin-ichiro Hagiwara, Takatoshi Maeyama, Hitoshi Honma, Masanobu Kawai, Kiwamu Akagi, Michiko Yasuhara, Naohiro Tomita and Yuri Etani

    Citation: BMC Gastroenterology 2021 21:60

    Content type: Case report

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  26. Pancreatic cancer (PC) is a devastating disease that has a poor prognosis and a total 5-year survival rate of around 5%. The poor prognosis of PC is due in part to a lack of suitable biomarkers that can allow ...

    Authors: Jiang Chen, Hongyu Li, Wenda Xu and Xiaozhong Guo

    Citation: BMC Gastroenterology 2021 21:58

    Content type: Research article

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  27. Bile acid malabsorption occurs in up to one third of patients with chronic diarrhoea of functional characteristics. The gold standard test for its diagnosis is the 75Selenium homocholic acid taurine (75SeHCAT) te...

    Authors: Virginia Flores, Helena Martínez-Lozano, Federico Bighelli, Javier Orcajo, Javier García-Lledó, Juan Carlos Alonso-Farto and Luis Menchén

    Citation: BMC Gastroenterology 2021 21:56

    Content type: Research article

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  28. Pathological angiogenesis is involved in the development of hepatocellular carcinoma. In patients with chronic hepatitis C (CHC), the level of angiogenic factor angiopoietin (ANGP)-2 is reported to be increase...

    Authors: Yosuke Osawa, Sachiyo Yoshio, Yoshihiko Aoki, Masaaki Korenaga, Masatoshi Imamura, Takashi Oide, Miku Okawara, Hironari Kawai, Yuriko Tsutsui, Yuichi Yoshida, Shiori Yoshikawa, Taizo Mori, Taiji Yamazoe and Tatsuya Kanto

    Citation: BMC Gastroenterology 2021 21:55

    Content type: Research article

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  29. Small intestinal bacterial overgrowth (SIBO) is characterized by the condition that bacteria overgrowth in the small intestine. Fecal microbiota transplantation (FMT) has been applied as an effective tool for ...

    Authors: Fenghua Xu, Ning Li, Chun Wang, Hanyang Xing, Dongfeng Chen and Yanling Wei

    Citation: BMC Gastroenterology 2021 21:54

    Content type: Research article

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  30. Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disord...

    Authors: Martina Ledergerber, Brian M. Lang, Henriette Heinrich, Luc Biedermann, Stefan Begré, Jonas Zeitz, Niklas Krupka, Andreas Rickenbacher, Matthias Turina, Thomas Greuter, Philipp Schreiner, René Roth, Alexander Siebenhüner, Stephan R. Vavricka, Gerhard Rogler, Niko Beerenwinkel…

    Citation: BMC Gastroenterology 2021 21:53

    Content type: Research article

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  31. Gastric ectopic pancreas (GEPs) is a rare developmental anomaly which is difficult to differentiate it from submucosal tumor such as gastric stromal tumor (GST) by imaging methods. Since the treatments of the ...

    Authors: Chang Liu, Fang Yang, Wenming Zhang, Weiqun Ao, Yongyu An, Cui Zhang, Bailing Dai, Cailing Pu and Jian Wang

    Citation: BMC Gastroenterology 2021 21:52

    Content type: Research article

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  32. To compare oncological results and safety profile of balloon micro-catheter trans-arterial chemoembolization (b-TACE) and drug-eluting-microsphere (DEM-TACE) in patients with hepatocellular-carcinoma (HCC).

    Authors: Pierleone Lucatelli, Gianluca De Rubeis, Bianca Rocco, Fabrizio Basilico, Alessandro Cannavale, Aurelio Abbatecola, Pier Giorgio Nardis, Mario Corona, Stefania Brozetti, Carlo Catalano and Mario Bezzi

    Citation: BMC Gastroenterology 2021 21:51

    Content type: Research article

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  33. Aortoenteric fistula (AEF) is a rare cause of gastrointestinal bleeding and is often misdiagnosed in clinical practice. Herein, a case series of AEFs are presented and the clinical characteristics, diagnosis, ...

    Authors: Jia Luo, Wen Tang, Mengran Wang, Yao Xiao, Manhong Tan and Chunyan Jiang

    Citation: BMC Gastroenterology 2021 21:49

    Content type: Research article

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  34. Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disease characterized by chronic abdominal discomfort and pain. The mechanisms of abdominal pain, as a relevant symptom, in IBS are...

    Authors: Zhongyuan Lin, Yimin Wang, Shiqing Lin, Decheng Liu, Guohui Mo, Hui Zhang and Yunling Dou

    Citation: BMC Gastroenterology 2021 21:48

    Content type: Research article

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  35. Leiomyoma is the most common benign oesophageal tumour. Half of all leiomyoma patients have oesophagus-associated complaints, such as dysphagia and epigastric pain, and the other 50% are asymptomatic with a di...

    Authors: László Andrási, Zoltán Szepes, László Tiszlavicz, György Lázár and Attila Paszt

    Citation: BMC Gastroenterology 2021 21:47

    Content type: Case report

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  36. Aorto-esophageal fistula (AEF) caused by foreign bodies ingestion is a rare but devastating disorder. Thoracic endovascular aortic repair (TEVAR) has become a widely accepted intervention for treating aorto-es...

    Authors: Yu-Yan Zhang, Shan Li, Xiang-Lei Yuan and Bing Hu

    Citation: BMC Gastroenterology 2021 21:46

    Content type: Case report

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  37. Upper gastrointestinal (GI) bleeding is the most important presentation of an aorto-duodenal fistula (ADF). Early diagnosis is difficult, and the disease is associated with high mortality. The present study ai...

    Authors: Chikamasa Ichita, Akiko Sasaki, Chihiro Sumida, Karen Kimura, Takashi Nishino, Junichi Tasaki, Sakue Masuda, Kazuya Koizumi, Jun Kawachi and Makoto Kako

    Citation: BMC Gastroenterology 2021 21:45

    Content type: Research article

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  38. This study evaluates preliminary results of image-guided percutaneous direct pancreatic duct intervention in the management of pancreatic fistula after surgery or pancreatitis when initially ineligible for sur...

    Authors: Xi Li, Ricardo Paz-Fumagalli, Weiping Wang, Beau B. Toskich, John A. Stauffer, Gregory T. Frey, J. Mark McKinney and Justin H. Nguyen

    Citation: BMC Gastroenterology 2021 21:44

    Content type: Research article

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  39. A series of evidence revealed that body mass index was an important confounding factor in the research of uric acid and ischemic heart disease/hypertension. The objective of this study was to investigate wheth...

    Authors: Mimi Zhou, Nan Yang, Xin Xing, Danyan Chang, Juan Li, Jiang Deng, Yi Chen, Chunhua Hu, Rou Zhang, Xiaolan Lu, Yingren Zhao and Yingli He

    Citation: BMC Gastroenterology 2021 21:43

    Content type: Research article

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  40. Nutrition is a modifiable risk factor that plays an important role in the prevention or delaying of the onset of non-alcoholic fatty liver disease (NAFLD). Previous studies have focused on NAFLD and individual...

    Authors: Ammar Salehi-sahlabadi, Samaneh Sadat, Sara Beigrezaei, Makan Pourmasomi, Awat Feizi, Reza Ghiasvand, Amir Hadi, Cain C. T. Clark and Maryam Miraghajani

    Citation: BMC Gastroenterology 2021 21:41

    Content type: Research article

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  41. Gastrointestinal tumor bleeding remains a clinical challenge because it is difficult to treat with conventional endoscopic hemostatic options. Recently, an endoscopic hemostatic powder (UI-EWD) was developed a...

    Authors: Jongbeom Shin, Boram Cha, Jin-Seok Park, Weonjin Ko, Kye Sook Kwon, Jin-Woo Lee, Hyung Kil Kim and Yong Woon Shin

    Citation: BMC Gastroenterology 2021 21:40

    Content type: Research article

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  42. A wide variation of causes can lead to gastrointestinal symptoms in children- an infection with parasites is one of them. The expansion of international travel might lead to an increase in testing children for...

    Authors: Corinne Légeret, Céline Rüttimann, Hans Fankhauser and Henrik Köhler

    Citation: BMC Gastroenterology 2021 21:39

    Content type: Research article

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  43. Adenocarcinoma in Esophagogastric Junction (AEG) is a severe gastrointestinal malignancy with a unique clinicopathological feature. Hence, we aimed to develop a competing risk nomogram for predicting survival ...

    Authors: Tongbo Wang, Yan Wu, Hong Zhou, Chaorui Wu, Xiaojie Zhang, Yingtai Chen and Dongbing Zhao

    Citation: BMC Gastroenterology 2021 21:38

    Content type: Research article

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  44. The Korean National Cancer Screening Program has been providing annual fecal immunochemical test for colorectal cancer (CRC) to adults aged 50 years and older since 2004. The Korean Colonoscopy Screening Pilot...

    Authors: Bomi Park, Jae Kwan Jun, Byung Chang Kim, Kui Son Choi and Mina Suh

    Citation: BMC Gastroenterology 2021 21:36

    Content type: Study protocol

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