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  1. The prognosis of hepatocellular carcinoma (HCC) has been extensively studied. However, the impact on prognosis of stage I HCC has not been well studied at clincopathological, mutational and transcriptional lev...

    Authors: Zhiqiang Li, Hongqiang Gao, Xiang Zhang, Qiyu Liu and Gang Chen
    Citation: BMC Gastroenterology 2022 22:427
  2. Inflammatory bowel disease (IBD) has become a global public health problem. The prevalence of IBD in China increased annually in past two decades.

    Authors: Jianfeng Luo, Jiamin Zhong, Haiwen Li, Shijing Zhang, Liwan Zhang, Jiang-tao Hou, Junyu Ke, Huibiao Li, Fengbin Liu and Xin-lin Chen
    Citation: BMC Gastroenterology 2022 22:426
  3. New direct-acting antiviral therapies have revolutionized hepatitis C virus (HCV) infection therapy. Nonetheless, once liver cirrhosis is established, the risk of hepatocellular carcinoma (HCC) still exists de...

    Authors: Shen-Shong Chang, Hsiao-Yun Hu, Yu-Chin Chen, Yung-Feng Yen and Nicole Huang
    Citation: BMC Gastroenterology 2022 22:425
  4. Colonoscopy is a standard procedure for evaluating colon diseases and screening for colorectal cancer, and bowel cleanliness prior to colonoscopy is key. The aim of this study was to compare the bowel cleansin...

    Authors: Apichet Sirinawasatien, Pallop Sakulthongthawin, Kanokpoj Chanpiwat and Tanyaporn Chantarojanasiri
    Citation: BMC Gastroenterology 2022 22:424
  5. Differential diagnosis between tuberculous peritonitis and peritoneal carcinomatosis remains challenging in clinical practice; thus, in-patients diagnosed with tuberculous peritonitis or peritoneal carcinomato...

    Authors: Li Du, Xiuqi Wei, Zhuanglong Xiao, Hui Wang and Yuhu Song
    Citation: BMC Gastroenterology 2022 22:423
  6. The aim of our study was to investigate the clinical characteristics and pathogenesis of tumor-induced acute pancreatitis (AP), and to develop a reliable prediction model of the clinical features to guide the ...

    Authors: Linlin Zheng, Ping Zhao, Xiaoqian Peng, Yunhui Zhou, Yichen Bao, Yuling Sun and Lin Zhou
    Citation: BMC Gastroenterology 2022 22:422
  7. Biomarkers such as fecal calprotectin (FC) and fecal immunochemical occult blood tests (FIT) for ulcerative colitis (UC) are used in clinical practice. In this study, the effect of UC disease duration on FC wa...

    Authors: Natsuki Ishida, Masanao Kaneko, Yusuke Asai, Takahiro Miyazu, Satoshi Tamura, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta and Ken Sugimoto
    Citation: BMC Gastroenterology 2022 22:420
  8. Evidence regarding the relationship between serum uric acid-to-creatinine (SUA/Scr) ratio and non-alcoholic fatty liver disease (NAFLD) in Chinese non-obese people is still limited. Therefore, the present stud...

    Authors: Xiaoyu Wang, Yong Han, Yufei Liu and Haofei Hu
    Citation: BMC Gastroenterology 2022 22:419
  9. Early hepatocellular carcinoma (HCC) detection with non-invasive biomarkers remains an unmet clinical need. We aimed to construct a predictive model based on the pre-diagnostic levels of serum markers to predi...

    Authors: Liming Zheng, Zeyu Huang, Xiaoping Li, Meifang He, Xiaoqin Liu, Guojun Zheng, Xike Zhou and Longgen Liu
    Citation: BMC Gastroenterology 2022 22:418
  10. Endoscopic submucosal dissection (ESD) can provide a high en bloc resection rate and has been widely applied as curative treatment for early colorectal cancer (ECC). However, surgical treatment is occasionally...

    Authors: Jongbeom Shin, Eun Ran Kim, Hyun Joo Jang, Dong Hoon Baek, Dong-Hoon Yang, Bo-In Lee, Kwang Bum Cho, Jin Woong Cho, Sung-Ae Jung, Su Jin Hong and Bong Min Ko
    Citation: BMC Gastroenterology 2022 22:417
  11. Clarithromycin-based therapy is important for Helicobacter pylori eradication treatment. However, clarithromycin may increase cardiovascular risk. Hence, we investigated the association between clarithromycin use...

    Authors: Yen-Chun Chen, Yi-Da Li, Ben-Hui Yu and Yi-Chun Chen
    Citation: BMC Gastroenterology 2022 22:416
  12. Recent data based on large databases show that bowel preparation (BP) is associated with improved outcomes in patients undergoing elective colorectal surgery. However, it remains unclear whether BP in elective...

    Authors: Haoran Zhuo, Zheng Liu, Benjamin J. Resio, Jialiang Liu, Xishan Wang, Kevin Y. Pei and Yawei Zhang
    Citation: BMC Gastroenterology 2022 22:415
  13. The effectiveness of pancreatic duct (PD) stenting in the early stages of acute pancreatitis (AP) remains controversial. This study aimed to investigate the efficacy and safety of PD stenting in the early stag...

    Authors: Weijie Yao, Genwang Wang, Qi Wang, Feng Wang, Zuoquan Wang and Zuozheng Wang
    Citation: BMC Gastroenterology 2022 22:414
  14. One of the most important risk factors for Helicobacter pylori (H. pylori) infection is nutrition. Balanced diets with high antioxidant properties may have protective effects against the consequences of this i...

    Authors: Zohreh Ebrahimi, Mohsen Masoodi, Zahra Aslani, Sina Naghshi, Masoumeh Khalighi Sikaroudi and Farzad Shidfar
    Citation: BMC Gastroenterology 2022 22:413
  15. Guillain–Barré Syndrome is an immune mediated polyneuropathy. Ulcerative Colitis is an immune mediated chronic inflammatory condition mainly of the large intestine. Guillain–Barré Syndrome can present as a rar...

    Authors: Jayasundara Mudiyanselage Hishali Dahami Jayasundara, Vajira Tharanga Samarawickrama, Ranjith Peiris, Tilan Aponso and Danushi Abeynayake
    Citation: BMC Gastroenterology 2022 22:411
  16. Malignancy-related ascites accounts for approximately 10% of causes of ascites. Our AIM was to characterize the ascites fluid and correlate clinical outcomes in those with extrahepatic malignancy and ascites.

    Authors: Omar Alshuwaykh, Amanda Cheung, Aparna Goel, Allison Kwong, Renumathy Dhanasekaran, T. Tara Ghaziani, Aijaz Ahmed, Tami Daugherty, Deepti Dronamraju, Radhika Kumari, Mindie Nguyen, W. Ray Kim and Paul Yien Kwo
    Citation: BMC Gastroenterology 2022 22:410
  17. T1 colorectal cancers have a low lymph node metastasis rate and good prognosis. Thus, endoscopic resection is an attractive choice. This study aimed to describe the value of poorly differentiated cluster grade...

    Authors: Xiaolin Ji, Mei Kang, Xianzhi Zhao, Xiaoyu Li, Yingjie Guo, Ping Xie, Yanan Yu and Zibin Tian
    Citation: BMC Gastroenterology 2022 22:409
  18. Serum ferritin (SF), as an acute-phase response protein, is used to reflect the degree of oxidative stress and systemic inflammatory responses. This study was designed to assess the effect of elevated SF level...

    Authors: Jie Wang, Qing-xie Liu, Dong-ling Teng, Yan-bing Ding, Guo-tao Lu, Wei-juan Gong, Qing-tian Zhu, Fei Han and Wei-ming Xiao
    Citation: BMC Gastroenterology 2022 22:408
  19. Gastric lymphangioma is one of the highly rare benign tumors characterized by multilocular or unilocular lymphatic spaces. Herein, we report a case of lymphangioma in the gastric antrum.

    Authors: Kunhao Bai, Yujun Dai, Chen Jiang, Shiyong Lin and Guobao Wang
    Citation: BMC Gastroenterology 2022 22:407
  20. Common variable immunodeficiency (CVID) is a rare disease that affects children and adults and is often difficult to diagnose. Despite being one of the most frequent causes of immunodeficiency, involving gastr...

    Authors: Mariana Barros Marcondes, Cíntia Mitsue Pereira Susuki, Newton Key Hokama, Paula de Oliveira Montandon Hokama, Felipe Aguera Oliver, Paulo Sergio Chaib, Xingshun Qi and Fernando Gomes Romeiro
    Citation: BMC Gastroenterology 2022 22:406
  21. In acute pancreatitis, secondary infection of pancreatic necrosis is a complication that mostly necessitates interventional therapy. A reliable prediction of infected necrotizing pancreatitis would enable an e...

    Authors: Mats L. Wiese, Steffi Urban, Sabrina von Rheinbaben, Fabian Frost, Matthias Sendler, Frank Ulrich Weiss, Robin Bülow, Marie-Luise Kromrey, Quang Trung Tran, Markus M. Lerch, Birgit Schauer and Ali A. Aghdassi
    Citation: BMC Gastroenterology 2022 22:405
  22. Ischemia–reperfusion injury (IRI) is the pathophysiological hallmark of hepatic dysfunction after orthotopic liver transplantation (OLT). Related to IRI, early allograft dysfunction (EAD) after OLT affects sho...

    Authors: Katja Frick, Elisabeth A. Beller, Marit Kalisvaart, Philipp Dutkowski, Reto A. Schüpbach and Stephanie Klinzing
    Citation: BMC Gastroenterology 2022 22:404
  23. Systemic pro-inflammatory factors play a critical role in mediating severe postoperative complications (SPCs) in upper abdominal surgery (UAS). The systemic immune-inflammation index (SII) has been identified ...

    Authors: Yang Jiao, Xiao Zhang, Mei Liu, Yu’e Sun, Zhengliang Ma, Xiaoping Gu, Wei Gu and Wei Zhu
    Citation: BMC Gastroenterology 2022 22:403
  24. The present study investigates if common missense functional variants p.I148M and p.E167K in PNPLA3 and TM6SF2 genes, respectively, associate with development of hepatic fibrosis and cirrhosis in a geographically...

    Authors: Bisma Rauff, Badr Alzahrani, Shafiq A. Chudhary, Bilal Nasir, Saqib Mahmood, Munir Ahmad Bhinder, Muhammad Faheem and Ali Amar
    Citation: BMC Gastroenterology 2022 22:401
  25. Hepatocellular carcinoma (HCC) is a serious malignant disease with high incidence, high mortality and poor prognosis. This study aimed to establish a novel signature based on apoptosis-related genes (ARGs) to ...

    Authors: Xiqin Wang and Chenguang Ji
    Citation: BMC Gastroenterology 2022 22:400
  26. Currently, the effect of skeletal muscle loss during neoadjuvant imatinib therapy on clinical outcomes in patients with locally advanced gastrointestinal stromal tumors (LA-GIST) remains unclear. This study ai...

    Authors: Ping’an Ding, Honghai Guo, Xiaoxiao He, Chenyu Sun, Scott Lowe, Rachel Bentley, Qin Zhou, Peigang Yang, Yuan Tian, Yang Liu, Li Yang and Qun Zhao
    Citation: BMC Gastroenterology 2022 22:399
  27. This study aimed to determine which running pattern of the left gastric vein (LGV) is most frequently ligated in subtotal stomach-preserving pancreatoduodenectomy (SSPPD) and how LGV ligation affects delayed g...

    Authors: Koichi Kimura, Ryosuke Minagawa, Takuma Izumi, Akihiko Otake, Takehiko Aoyagi, Daisuke Taniguchi, Hiroko Yano, Yuichiro Kajiwara, Kazuhito Minami and Takashi Nishizaki
    Citation: BMC Gastroenterology 2022 22:398
  28. Authors: Ryosuke Miyazaki, Toshiyuki Sakurai, Mariko Shimada, Yuko Iwashita, Naoki Shibuya, Yoshihiro Akita, Haruna Miyashita, Yuki Maruyama and Masayuki Saruta
    Citation: BMC Gastroenterology 2022 22:397

    The original article was published in BMC Gastroenterology 2022 22:310

  29. Although major complication rates following percutaneous liver biopsy (PLB) have been reported to be higher in children than in adults, scarce data are available regarding pediatric patients stratified by nati...

    Authors: Kayo Ikeda Kurakawa, Akira Okada, Kazuhiko Bessho, Taisuke Jo, Sachiko Ono, Nobuaki Michihata, Ryosuke Kumazawa, Hiroki Matsui, Kiyohide Fushimi, Satoko Yamaguchi, Toshimasa Yamauchi, Masaomi Nangaku, Takashi Kadowaki and Hideo Yasunaga
    Citation: BMC Gastroenterology 2022 22:395
  30. No previous studies have examined the possible relationship between intraductal papillary mucinous neoplasm (IPMN) and the developmental ductal variations of the pancreas, such as an ansa pancreatica and a mea...

    Authors: Katarina Johansson, Harri Mustonen, Hanna Seppänen and Tiina E. Lehtimäki
    Citation: BMC Gastroenterology 2022 22:394
  31. Covid-19 is a pandemic disease that is more severe and mortal in people with immunodeficiency, such as those with inflammatory bowel disease (IBD). On the other hand, no definitive treatment has been identifie...

    Authors: Elham Tabesh, Maryam Soheilipour, Mohammad Rezaeisadrabadi, Elahe Zare-Farashbandi and Razieh Sadat Mousavi-Roknabadi
    Citation: BMC Gastroenterology 2022 22:393
  32. Napsin B Aspartic Peptidase, Pseudogene (NAPSB) was associated with CD4 + T cell infiltration in pancreatic ductal adenocarcinoma. However, the biological role of NAPSB in hepatocellular carcinoma (HCC) remain...

    Authors: Yu-Mei Ning, Kun Lin, Xiao-Ping Liu, Yang Ding, Xiang Jiang, Zhang Zhang, Yu-Ting Xuan, Li Dong, Lan Liu, Fan Wang, Qiu Zhao, Hai-Zhou Wang and Jun Fang
    Citation: BMC Gastroenterology 2022 22:392
  33. Painless gastrointestinal endoscopy is widely used for the diagnosis and treatment of digestive diseases. At present, propofol is commonly used to perform painless gastrointestinal endoscopy, but the high dose...

    Authors: Yongtong Zhan, Shuqing Liang, Zecheng Yang, Qichen Luo, Shuai Li, Jiamin Li, Zhaojia Liang and Yalan Li
    Citation: BMC Gastroenterology 2022 22:391
  34. Multi-matrix mesalazine (MMX) is an important treatment for ulcerative colitis (UC); however, it is often excreted intact, which increases the risk of relapse. This study aimed to clarify the risk factors for ...

    Authors: Ohtaki Yuichiro, Uchiyama Kan, Kamiya Hirotaka, Moriizumi Eri, Yamada Moe, Aoki Yuma, Watanabe Toshimune, Kiryu Sachie, Suzuki Sizuka, Matsumoto Yoshihiro, Ito Zensho, Ohkusa Toshifumi, Koido Shigeo and Saruta Masayuki
    Citation: BMC Gastroenterology 2022 22:390
  35. The purpose of this systematic review is to evaluate whether self-expandable implantable vs non-self-expandable injectable bulking agents (second-line therapies) are equal/superior in terms of effectiveness (s...

    Authors: Lucia Gassner, Claudia Wild and Melanie Walter
    Citation: BMC Gastroenterology 2022 22:389
  36. Intra-abdominal desmoplastic small round cell tumors (IADSRCT) are rare and aggressive neoplasia that are resistant to chemotherapy. Anlotinib is an oral multi-target tyrosine kinase inhibitor that also has an...

    Authors: Ke Cheng, Xia Liu, Ye Chen, Kexun Zhou and ZhiPing Li
    Citation: BMC Gastroenterology 2022 22:388
  37. There are inadequate data and no histological evidence regarding the effects of antiviral treatment for hepatitis B e-antigen (HBeAg)-negative chronic hepatitis B (CHB) patients with normal or mildly elevated ...

    Authors: Sufang Wei, Meixin Hu, Hongjie Chen, Qiuli Xie, Peng Wang, Hong Li and Jie Peng
    Citation: BMC Gastroenterology 2022 22:387
  38. Perforations related to endoscopic retrograde cholangiopancreatography (ERCP) are rare but life-threatening complications. The treatment of Type-II-periampullary perforations that develop during endoscopic sph...

    Authors: Osman Bozbiyik, Bartu Cetin, Tufan Gumus, Fatih Tekin and Alper Uguz
    Citation: BMC Gastroenterology 2022 22:385
  39. Stool DNA (sDNA) tests and fecal immunochemical test (FIT) are used for the detection of colorectal cancer (CRC). Here we performed a novel evaluation using sDNA and FIT to assess their performance in CRC scre...

    Authors: Hongli Xu, Huixin Chen, Junjie Hu, Zhiguo Xiong, Dongqing Li, Shun Wang and Jing Yu
    Citation: BMC Gastroenterology 2022 22:384
  40. Familial adenomatous polyposis (FAP) is a rare autosomal dominant disease characterized by germline mutations in the Adenomatous Polyposis Coli (APC) gene, resulting in the development of numerous colorectal aden...

    Authors: Jasmijn D. G. Linssen, Sanne M. van Neerven, Arthur S. Aelvoet, Clara C. Elbers, Louis Vermeulen and Evelien Dekker
    Citation: BMC Gastroenterology 2022 22:383
  41. Endoscopic retrograde cholangiopancreatography (ERCP) is an essential procedure in the diagnosis and treatment of biliopancreatic diseases. The most common adverse event of ERCP is post-ERCP pancreatitis (PEP)...

    Authors: Shunjiro Azuma, Akira Kurita, Kenichi Yoshimura, Tomoaki Matsumori, Yosuke Kobayashi, Kei Yane, Osamu Inatomi, Kenji Sawada, Ryo Harada and Shujiro Yazumi
    Citation: BMC Gastroenterology 2022 22:382
  42. The role of consolidative chemotherapy (CCT) for locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients treated with definitive concurrent chemoradiotherapy (dCCRT) is unclear. We aimed to comp...

    Authors: Chen-Yuan Lin, Ming-Yu Lien, Chi-Ching Chen, Hsin-Yuan Fang, Yu-Sen Lin, Chien-Kuang Chen, Jian-Xun Chen, Ting-Yu Lu, Tzu-Min Huang, Te-Chun Hsieh, Shung-Shung Sun, Chia-Chin Li and Chun-Ru Chien
    Citation: BMC Gastroenterology 2022 22:381
  43. Cholestatic liver diseases are a major source of morbidity and mortality that can progress to end-stage liver disease and hyperbilirubinemia is a hallmark of cholestasis. There are few effective medical therap...

    Authors: Xiaoying Liu, Sarah A. Taylor, Stela Celaj, Josh Levitsky and Richard M. Green
    Citation: BMC Gastroenterology 2022 22:380
  44. Post-operative pain is the main problem of hemorrhoidectomy. An adequate pain management can promote early mobilization, fast recovery, and reduce hospitalization costs. This study aimed to investigate the rol...

    Authors: Imam Sofii, Handy Darmawan, Amelia Sophia Ramadhini, Fauzan Kurniawan and Ahmad Shafa Hanif
    Citation: BMC Gastroenterology 2022 22:379
  45. The natural history of intracholecystic papillary neoplasm (ICPN), especially the speed of growth from small benign to a carcinomatous lesion, is quite unrevealed. Here, we report an extremely rare case of ICP...

    Authors: Daisuke Koike, Hiroyuki Kato, Yukio Asano, Masahiro Ito, Satoshi Arakawa, Norihiko Kawabe, Masahiro Shimura, Chihiro Hayashi, Takayuki Ochi, Kenshiro Kamio, Toki Kawai, Hironobu Yasuoka, Takahiko Higashiguchi and Akihiko Horiguchi
    Citation: BMC Gastroenterology 2022 22:377

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