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  1. Ulcerative colitis is a common non-specific chronic disease. Supplementing probiotics has become an important method for the treatment of ulcerative colitis. This study aimed to explore the effect of supplemen...

    Authors: Shuying Li, Yan Yin, Dan Xiao and Yong Zou

    Citation: BMC Gastroenterology 2021 21:314

    Content type: Research

    Published on:

  2. Chemoradiation with capecitabine followed by surgery is standard care for locally advanced rectal cancer (LARC). Severe diarrhea is considered a dose-limiting toxicity of adding capecitabine to radiation thera...

    Authors: J. M. van Rees, W. Hartman, J. J. M. E. Nuyttens, E. Oomen-de Hoop, J. L. A. van Vugt, J. Rothbarth, C. Verhoef and E. van Meerten

    Citation: BMC Gastroenterology 2021 21:313

    Content type: Research article

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  3. Deep remission (DR) is a treatment target in IBD associated with reduced hospitalization and improved outcome. Randomized control trial (RCT) data demonstrates efficacy of anti-TNFα agents in achieving DR; how...

    Authors: Omeed Alipour, Alakh Gualti, Ling Shao and Bing Zhang

    Citation: BMC Gastroenterology 2021 21:312

    Content type: Research article

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  4. Genetic variations within the regulatory region of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated with Crohn’s Disease (CD). NLRP3 is part of the NLRP3-inflammasome tha...

    Authors: Priyatharsan Yoganathan, Jean-Benoit Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc, Luc Biedermann, Benjamin Misselwitz, Martin Hausmann, Gerhard Rogler, Michael Scharl and Isabelle Frey-Wagner

    Citation: BMC Gastroenterology 2021 21:310

    Content type: Research article

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  5. Irritable bowel syndrome (IBS) appears to have a bidirectional interaction with both depressive and anxiety-related complaints. However, it remains unclear how exactly the psychological complaints, at the indi...

    Authors: Felicitas Engel, Tatjana Stadnitski, Esther Stroe-Kunold, Sabrina Berens, Rainer Schaefert and Beate Wild

    Citation: BMC Gastroenterology 2021 21:309

    Content type: Case report

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  6. Endoscopic submucosal dissection (ESD) is gradually turning into the standard treatment for superficial esophageal squamous cell carcinoma (SESCC), however, the long-term outcomes have hardly ever been reporte...

    Authors: Ming-Hung Hsu, Wen-Lun Wang, Tzu-Haw Chen, Chi-Ming Tai, Hsiu-Po Wang and Ching-Tai Lee

    Citation: BMC Gastroenterology 2021 21:308

    Content type: Research

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  7. As right colon polyps are challenging to detect, a retroflexed view of right colon (RV) may be useful. However, cecal retroflexion (CR) without a RV to the hepatic flexure (HF) is inadequate. We aimed to deter...

    Authors: Rajesh N. Keswani, Charles J. Kahi, Mark Benson, Andrew J. Gawron, Tonya R. Kaltenbach, Rena H. Yadlapati, Dyanna L. Gregory and Anna Duloy

    Citation: BMC Gastroenterology 2021 21:307

    Content type: Research article

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  8. We previously reported on the trends in the etiologies of hepatocellular carcinoma (HCC) diagnosed in patients between 1995 and 2009. The aims of our updated study were to evaluate the incidence, nonhepatitis...

    Authors: Yuko Nagaoki, Hideyuki Hyogo, Yuwa Ando, Yumi Kosaka, Shinsuke Uchikawa, Yuno Nishida, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Wataru Okamoto, Tomokazu Kawaoka, Masataka Tsuge…

    Citation: BMC Gastroenterology 2021 21:306

    Content type: Research article

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  9. Gongylonema pulchrum is a zoonotic parasite rarely found in humans. To date, there have been no reports on the carcinogenic properties of G. pulchrum, and there are few reports overall on the relationship between...

    Authors: Qiaozhi Zhou, Yongqiu Wei, Huihong Zhai, Shaogang Li, Rui Xu and Peng Li

    Citation: BMC Gastroenterology 2021 21:305

    Content type: Case report

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  10. Acute pancreatitis (AP) is an inflammatory disorder that causes a considerable economic health burden. While the overall mortality is low, around 20% of patients have a complicated course of disease resulting ...

    Authors: C. Ammer-Herrmenau, T. Asendorf, G. Beyer, S. M. Buchholz, S. Cameron, M. Damm, F. Frost, R. Henker, R. Jaster, V. Phillip, M. Placzek, C. Ratei, S. Sirtl, T. van den Berg, M. J. Weingarten, J. Woitalla…

    Citation: BMC Gastroenterology 2021 21:304

    Content type: Study protocol

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  11. Epidemiological studies suggest an inverse association between H. pylori infection/exposure and inflammatory bowel disease prevalence/incidence, however, there are no reports of individual patients who developed ...

    Authors: J. Homolak, M. Nikolić, D. Potoč, M. Živković, D. Bakula, I. Budimir, I. Pavić, D. Hrabar, N. Ljubičić and D. Vražić

    Citation: BMC Gastroenterology 2021 21:303

    Content type: Case report

    Published on:

  12. Research has indicated a lack of disease-specific reproductive knowledge among patients with Inflammatory Bowel Disease (IBD) and this has been associated with increased “voluntary childlessness”. Furthermore,...

    Authors: Astrid-Jane Williams, Neda Karimi, Radha Chari, Susan Connor, Mary A. De Vera, Levinus A. Dieleman, Tawnya Hansen, Kathleen Ismond, Rshmi Khurana, Dawn Kingston, Katie O’Connor, Daniel C. Sadowski, Flora Fang-Hwa, Eytan Wine, Yvette Leung and Vivian Huang

    Citation: BMC Gastroenterology 2021 21:302

    Content type: Research

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  13. Authors: Kalliopi Foteinogiannopoulou, Konstantinos Karmiris, Georgios Axiaris, Magdalini Velegraki, Antonios Gklavas, Christina Kapizioni, Charalabos Karageorgos, Christina Kateri, Anastasia Katsoula, Georgios Kokkotis, Evgenia Koureta, Charikleia Lamouri, Panagiotis Markopoulos, Maria Palatianou, Ploutarchos Pastras, Konstantinos Fasoulas…

    Citation: BMC Gastroenterology 2021 21:301

    Content type: Correction

    Published on:

    The original article was published in BMC Gastroenterology 2021 21:269

  14. Intestinal perforations and fistulas are common complications of Crohn’s disease. However, chronic perforation with peritoneal space to rectal and vaginal fistulas have not been previously reported.

    Authors: Meng-Wu Chung, Chien-Ming Chen, Jun-Te Hsu, Ren-Chin Wu, Cheng-Tang Chiu, Chia-Jung Kuo, Ming-Yao Su and Puo-Hsien Le

    Citation: BMC Gastroenterology 2021 21:299

    Content type: Case report

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  15. Approximately 5.0–24.2% of colorectal cancers (CRCs) have inactivating mutations in SMAD4, making it one of the frequently mutated genes in CRC. We thus carried out a comprehensive system review and meta-analy...

    Authors: Tian Fang, Tingting Liang, Yizhuo Wang, Haitao Wu, Shuhan Liu, Linying Xie, Jiaying Liang, Chang Wang and Yehui Tan

    Citation: BMC Gastroenterology 2021 21:297

    Content type: Research

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  16. Bacterial infections are common in patients with decompensated liver cirrhosis and a leading cause of death. Reliable data on antibiotic resistance are required to initiate effective empiric therapy. We here a...

    Authors: Annika Hillert, Marie Schultalbers, Tammo L. Tergast, Ralf-Peter Vonberg, Jessica Rademacher, Heiner Wedemeyer, Markus Cornberg, Stefan Ziesing, Benjamin Maasoumy and Christoph Höner zu Siederdissen

    Citation: BMC Gastroenterology 2021 21:296

    Content type: Research

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  17. High-resolution anorectal manometry (HRAM) has been developed to improve measurement of anorectal functions. This study aims to identify normal HRAM values in healthy young Vietnamese adults.

    Authors: Le Manh Cuong, Ha Van Quyet, Tran Manh Hung, Nguyen Ngoc Anh, Tran Thu Ha, Vu Van Du, Do Van Loi, Ha Huu Hoang Khai and Vu Duy Kien

    Citation: BMC Gastroenterology 2021 21:295

    Content type: Research

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  18. The prognostic potential of early tumor shrinkage (ETS) and depth of response (DpR) in pancreatic cancer (PC) is unclear. Here, we recruited 90 patients with recurrent and metastatic PC (RMPC) who had received...

    Authors: Xiaojuan Yang, Xinghong Xian, Yongsheng Wang and Meng Qiu

    Citation: BMC Gastroenterology 2021 21:294

    Content type: Research

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  19. The chronic and progressive evolution of Inflammatory Bowel Diseases (IBD), with its prototypical fluctuating trend, creates a condition of psycho-social discomfort, impacting the quality of life in terms of p...

    Authors: E. Volpato, C. Bosio, E. Previtali, S. Leone, A. Armuzzi, F. Pagnini and G. Graffigna

    Citation: BMC Gastroenterology 2021 21:293

    Content type: Research

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  20. Recently, dietary restriction of fermentable carbohydrates (a low-FODMAP diet) in combination with a gluten-free diet (GFD) has been proposed to reduce the symptoms in irritable bowel syndrome (IBS) patients. ...

    Authors: Kaveh Naseri, Hossein Dabiri, Mohammad Rostami-Nejad, Abbas Yadegar, Hamidreza Houri, Meysam Olfatifar, Amir Sadeghi, Saeede Saadati, Carolina Ciacci, Paola Iovino and Mohammad Reza Zali

    Citation: BMC Gastroenterology 2021 21:292

    Content type: Research

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  21. Sometimes in clinical practice, it is a great challenge to distinguish Crohn's disease (CD) and intestinal tuberculosis (ITB), we conducted this study to identify simple and useful algorithm for distinguishin...

    Authors: Yi Lu, Yonghe Chen, Xiang Peng, Jiayin Yao, Weijie Zhong, Chujun Li and Min Zhi

    Citation: BMC Gastroenterology 2021 21:291

    Content type: Research

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  22. The effect of acute kidney injury (AKI) on patients with acute variceal bleeding (AVB) using the recently proposed International Club of Ascites (ICA) criteria is unclear. This study aimed to evaluate the inci...

    Authors: Jae Heon Kim, Chang Bin Im, Sang Soo Lee, Hankyu Jeon, Jung Woo Choi, Hee Jin Kim, Ra Ri Cha, Hyun Chin Cho, Jae Min Lee, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok-Jae Lee

    Citation: BMC Gastroenterology 2021 21:290

    Content type: Research

    Published on:

  23. Irritable bowel syndrome (IBS) is a debilitating and costly disorder. Cognitive behavior therapy (CBT) is effective in the treatment of IBS, both when delivered over the internet and in face-to-face settings. ...

    Authors: Hugo Wallén, Perjohan Lindfors, Erik Andersson, Erik Hedman-Lagerlöf, Hugo Hesser, Nils Lindefors, Cecilia Svanborg and Brjánn Ljótsson

    Citation: BMC Gastroenterology 2021 21:289

    Content type: Research

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  24. Minimal hepatic encephalopathy (MHE) is the presence of neuropsychological abnormalities detectable by psychometric tests. Psychometric Hepatic Encephalopathy Score (PHES) is a gold standard test for the early...

    Authors: Larissa Pessidjo Djomatcho, Mathurin Pierre Kowo, Antonin Ndjitoyap Ndam, Sylvain Raoul Simeni Njonnou, Gabin Ulrich Kenfack, Firmin Ankouane Andoulo, Servais Fiacre Eloumou Bagnaka, Winnie Tatiana Bekolo, Agnès Malongue, Isabelle Dang Babagna, Magloire Biwolé Sida, Henry Luma and Oudou Njoya

    Citation: BMC Gastroenterology 2021 21:287

    Content type: Research

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  25. Spontaneous hyperinflation is reported to the Food and Drug Administration as a complication of intragastric balloons. It is postulated that orogastric contamination of the intragastric balloon may cause this ...

    Authors: Fadi Hawa, Eric J. Vargas, Andres Acosta, Alison McRae, Fateh Bazerbachi and Barham K. Abu Dayyeh

    Citation: BMC Gastroenterology 2021 21:286

    Content type: Research

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  26. Terminal ileal (TI) ulcers are occasionally detected in asymptomatic individuals and mostly resolve without any treatment. In patients with ulcerative colitis (UC), TI ulcers are infrequently observed without ...

    Authors: Hyo-Jin Lim, Hyun Do Kim, Jae Seung Soh, Sung-Yeun Kim, Ye-Ji Jung, Hyun Lim, Ho Suk Kang and Jong Hyeok Kim

    Citation: BMC Gastroenterology 2021 21:285

    Content type: Research

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  27. Gastrointestinal adenocarcinoma (GIAD) has caused a serious disease burden globally. Targeted therapy for the transforming growth factor beta (TGF-β) signaling pathway is becoming a reality. However, the molec...

    Authors: Qiaofeng Zhang, Furong Liu, Lu Qin, Zhibin Liao, Jia Song, Huifang Liang, Xiaoping Chen, Zhanguo Zhang and Bixiang Zhang

    Citation: BMC Gastroenterology 2021 21:284

    Content type: Research

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  28. The prognostic values of preoperative tumor markers (TMs) remain elusive in patients with locally advanced gastric cancer (LAGC) after neoadjuvant chemotherapy treatment (NACT). This study aimed to assess and ...

    Authors: Zining Liu, Yinkui Wang, Fei Shan, Xiangji Ying, Yan Zhang, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Ziyu Li and Jiafu Ji

    Citation: BMC Gastroenterology 2021 21:283

    Content type: Research

    Published on:

  29. Authors: Pierleone Lucatelli, Gianluca De Rubeis, Bianca Rocco, Fabrizio Basilico, Alessandro Cannavale, Aurelio Abbatecola, Pier Giorgio Nardis, Mario Corona, Stefania Brozzetti, Carlo Catalano and Mario Bezzi

    Citation: BMC Gastroenterology 2021 21:282

    Content type: Correction

    Published on:

    The original article was published in BMC Gastroenterology 2021 21:51

  30. Fecal microbiota transplantation (FMT) is a promising new strategy in the treatment of Inflammatory Bowel Disease, but long-term delivery systems are lacking. This randomized study was designed as a safety and...

    Authors: Jessica W. Crothers, Nathaniel D. Chu, Le Thanh Tu Nguyen, Magen Phillips, Cheryl Collins, Karen Fortner, Roxana Del Rio-Guerra, Brigitte Lavoie, Peter Callas, Mario Velez, Aaron Cohn, Ryan J. Elliott, Wing Fei Wong, Elaine Vo, Rebecca Wilcox, Mark Smith…

    Citation: BMC Gastroenterology 2021 21:281

    Content type: Research

    Published on:

  31. Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is a rare but critical complication that develops in patients treated with MTX. Although MTX-LPD has been recently reported, the incidence of foll...

    Authors: Yui Osaki, Hideto Kawaratani, Hiroki Kachi, Kyohei Matsuura, Yuki Tsuji, Takahiro Ozutsumi, Hirotetsu Takagi, Masanori Furukawa, Yasuhiko Sawada, Akira Mitoro, Junichi Yamao and Hitoshi Yoshiji

    Citation: BMC Gastroenterology 2021 21:280

    Content type: Case report

    Published on:

  32. Eosinophilic gastrointestinal disorders, also known as eosinophilic gastroenteritis, are rare inflammatory conditions characterized by eosinophilic infiltration of different parts of the gastrointestinal tract...

    Authors: Emran A. El-Alali, Ibrahim M. Abukhiran and Tarik Z. Alhmoud

    Citation: BMC Gastroenterology 2021 21:279

    Content type: Case report

    Published on:

  33. Human Swayback is a disease characterized by acquired copper deficiency which primarily manifests as myeloneuropathy. Common causes include malabsorptive disorders, gastric surgery, total parenteral nutrition ...

    Authors: Blanca C. Lizaola-Mayo, Rolland C. Dickson, Dora M. Lam-Himlin and David M. Chascsa

    Citation: BMC Gastroenterology 2021 21:278

    Content type: Case report

    Published on:

  34. Telephone therapist delivered CBT (TCBT) and web-based CBT (WCBT) have been shown to be significantly more clinically effective than treatment as usual (TAU) at reducing IBS symptom severity and impact at 12 m...

    Authors: Paul McCrone, Hazel Everitt, Sabine Landau, Paul Little, Felicity L. Bishop, Gilly O’Reilly, Alice Sibelli, Rachel Holland, Stephanie Hughes, Sula Windgassen, Kim Goldsmith, Nicholas Coleman, Robert Logan, Trudie Chalder and Rona Moss-Morris

    Citation: BMC Gastroenterology 2021 21:276

    Content type: Research article

    Published on:

  35. Synthetic cannabinoids (SC) are chemical substances which activate cannabinoid receptors similarly to tetrahydrocannabinol, but with a higher efficacy. These substances are used as illicit recreational drugs, ...

    Authors: David Hakimian, Ariel A. Benson, Tawfik Khoury, Muhammad Massarwa, Sarah Israel, Shaden Salameh, Yonatan Gershinsky, Barak Shapira and Mordechai Muszkat

    Citation: BMC Gastroenterology 2021 21:274

    Content type: Research article

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  36. Haemolymphangioma arising from the small bowel and its mesentery is extremely rare in the clinical setting. To date, only 8 cases of small bowel haemolymphangioma have been reported, and there have been no pre...

    Authors: Yao Du, Jiang Nan Zhang, Lu Lu Zhu, Yi Wang and Wei Ping Li

    Citation: BMC Gastroenterology 2021 21:273

    Content type: Case report

    Published on:

  37. Lower gastrointestinal bleeding (LGIB) is very common in the hospital setting. Most bleedings stop spontaneously, but rare infectious causes of LGIB may lead to rapid and serious complications if left untreate...

    Authors: Ting-Hsuan Chiang, Yi-Wei Lee, Jui-Hsiang Tan, Chih-Chin Kao, Chun-Chao Chang and Kuan-Chieh Fang

    Citation: BMC Gastroenterology 2021 21:272

    Content type: Case report

    Published on:

  38. γδT cells play an important role in the mucosa inflammation and immunity-associated disorders. Our previous study reported that γδ T cells producing IL-17 were involved in the pathogenesis of post-infectious i...

    Authors: L. W. Dong, X. N. Sun, Z. C. Ma, J. Fu, F. J. Liu, B. L. Huang, D. C. Liang, D. M. Sun and Cheng Lan

    Citation: BMC Gastroenterology 2021 21:271

    Content type: Research article

    Published on:

  39. Tumor-to-tumor metastasis is the rare phenomenon in which one tumor exhibits metastatic deposits from another. To the best of our knowledge, there has been no prior reported case of tumor-to-tumor metastasis o...

    Authors: Yusuke Kamihara, Sayaka Murai, Shohei Kikuchi, Akinori Wada, Jun Murakami, Nam H. Dang and Tsutomu Sato

    Citation: BMC Gastroenterology 2021 21:270

    Content type: Case report

    Published on:

  40. Anemia is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD) affecting negatively the patients’ quality of life. The aim of this study was to determine the frequency and real-life manag...

    Authors: Kalliopi Foteinogiannopoulou, Konstantinos Karmiris, Georgios Axiaris, Magdalini Velegraki, Antonios Gklavas, Christina Kapizioni, Charalabos Karageorgos, Christina Kateri, Anastasia Katsoula, Georgios Kokkotis, Evgenia Koureta, Charikleia Lamouri, Panagiotis Markopoulos, Maria Palatianou, Ploutarchos Pastras, Konstantinos Fasoulas…

    Citation: BMC Gastroenterology 2021 21:269

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Gastroenterology 2021 21:301

  41. Alcohol is the main cause of chronic liver disease. The Enhanced Liver Fibrosis (ELF) test is a serological biomarker for fibrosis staging in chronic liver disease, however its utility in alcohol-related liver...

    Authors: Declan Connoley, Preya Janubhai Patel, Brian Hogan, Sudeep Tanwar, Freya Rhodes, Julie Parkes, Alastair Burt, Jennifer Watkins, William Sievert and William Rosenberg

    Citation: BMC Gastroenterology 2021 21:268

    Content type: Research

    Published on:

  42. Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic kidney disease and polycystic liver disease is its major extrarenal manifestation, however biliary peritonitis due to a liver c...

    Authors: Hiroshi Matsuo, Kan Katayama, Aoi Hayasaki, Yusuke Iizawa, Mayumi Endo, Tomohiro Murata, Shugo Mizuno and Kaoru Dohi

    Citation: BMC Gastroenterology 2021 21:267

    Content type: Case report

    Published on:

  43. The rapid growth of Qatar in the last two decades has attracted a large influx of immigrant workers who mostly come from HEV-hyperendemic countries. Thus, we aim to investigate the prevalence of HEV among acut...

    Authors: Enas S. Al Absi, Duaa W. Al-Sadeq, Makiyeh Khalili, Nadin Younes, Nader Al-Dewik, Sara K. Abdelghany, Somaia S. Abouzid, Asma A. Al Thani, Hadi M. Yassine, Peter V. Coyle and Gheyath K. Nasrallah

    Citation: BMC Gastroenterology 2021 21:266

    Content type: Research article

    Published on:

  44. Hepatocellular carcinoma (HCC), one of the most common malignant tumors worldwide, ranks as the fifth most common cancer and has been the second most frequent cause of cancer-related death. RNA binding protein...

    Authors: Zeng-Hong Wu, Hong-Ming Huang and Dong-Liang Yang

    Citation: BMC Gastroenterology 2021 21:265

    Content type: Research article

    Published on:

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