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Table 1 Mean copy number per cell for the 12 DNA targets tested in esophageal mucosa of chagasic megaesophagus and normal mucosa groups.

From: Chromosomal imbalances are uncommon in chagasic megaesophagus

  CM NM  
Targets Mucosa Layers   Mucosa Layers   t-Student
CM × NM
  Superficial Basal Total Superficial Basal Total  
  Mean ± SD Mean ± SD  
FHIT 1.77 ± 0.08 1.78 ± 0.08 1.76 ± 0.08 1.35 ± 0.49 1.75 ± 0.04 1.74 ± 0.04 ns P = 0.7803
  Range: 1.56-1.90 Range: 1.71-1.77  
PIK3CA 1.76 ± 0.09 1.78 ± 0.08 1.77 ± 0.07 1.70 ± 0.09 1.78 ± 0.11 1.74 ± 0.01 ns P = 0.6982
  Range: 1.56-1.96 Range: 1.64-1.86  
TP63 1.77 ± 0.11 1.78 ± 0.09 1.77 ± 0.09 1.70 ± 0.09 1.78 ± 0.11 1.74 ± 0.01 ns P = 0.5304
  Range: 1.56-2.06 Range: 1.64-1.86  
EGFR 1.52 ± 0.12a 1.45 ± 0.15b 1.49 ± 0.13a, b 1.60 ± 0.00 1.74 ± 0.01 1.67 ± 0.01 nsP = 0.3700
  Range: 1.25-1.80 Range: 1.60-1.75  
FGFR1 1.78 ± 0.01 1.76 ± 0.10 1.77 ± 0.08 1.63 ± 0.01 1.70 ± 0.03 1.67 ± 0.03 ns P = 0.2200
  Range: 1.56-2.22 Range: 1.62-1.72  
MYC 1.76 ± 0.09 1.75 ± 0.09 1.76 ± 0.08 1.66 ± 0.01 1.74 ± 0.02 1.70 ± 0.01 ns P = 0.5396
  Range: 1.58-1.77 Range: 1.69-1.70  
CDKN2A 1.49 ± 0.08 1.50 ± 0.07 1.50 ± 0.06 1.76 ± 0.14 1.72 ± 0.01 1.74 ± 0.07 * P < 0.0001
  Range: 1.34-1.59 Range: 1.69-1.79  
YES1 1.67 ± 0.13 1.67 ± 0.12 1.67 ± 0.11 1.70 ± 0.08 1.68 ± 0.13 1.69 ± 0.07 ns P = 0.8099
  Range: 1.37-1.99 Range: 1.58-1.75  
NCOA3 1.65 ± 0.11 1.64 ± 0.11 1.64 ± 0.10 1.66 ± 0.11 1.61 ± 0.01 1.64 ± 0.06 ns P = 0.7656
  Range: 1.37-1.80 Range: 1.59-1.68  
Centromere 3 1.77 ± 0.08 1.79 ± 0.07 1.77 ± 0.07 1.71 ± 0.07 1.76 ± 0.08 1.74 ± 0.08 nsP = 0.6638
  Range: 1.56-1.90 Range: 1.68-1.79  
Centromere 7 1.53 ± 0.12 1.50 ± 0.16 1.52 ± 0.13 1.67 ± 0.01 1.79 ± 0.04 1.73 ± 0.21 nsP = 0.1235
  Range: 1.26-1.53 Range: 1.76-1.82  
Centromere 9 1.53 ± 0.09 1.53 ± 0.09 1.53 ± 0.07 1.77 ± 0.15 1.77 ± 0.04 1.77 ± 0.10 * P = 0.0002
  Range: 1.33-1.65 Range: 1.70-1.84  
  1. CM, chagasic megaesophagus; NM, normal mucosa; SD, standard-deviation; Statistical Analysis: t-Student; *, P < 0.05; ns, P > 0.05; a, b, P = 0.008.