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Table 5 Adverse events and dose modifications according to treatment group.

From: Short versus standard treatment with pegylated interferon alfa-2A plus ribavirin in patients with hepatitis C virus genotype 2 or 3: the cleo trial

 

Group A1

n = 72

Group A2

n = 71

Group B

n = 67

Total Discontinuation n(%)

0

5 (7.0)

7 (10)*

   -anemia

0

3

3

   -neutropenia

0

1

2

   -depression

0

0

1

   -ulcerative colitis

0

1

0

   -cough

0

0

1

Dose modification n(%)

   

   -Peginterferon

1 (1)

2 (3)

2 (3)

   -Ribavirin

2 (3)

9 (12)

9 (13)

Adverse events n(%)

   

   -Anemia

5 (7)

6 (8)

6 (9)

   -Neutropenia

2 (3)

1 (1)

2 (3)

   -Depression

2 (3)

2 (3)

1 (1)

   -Cutaneous rash

0

0

1 (1)

   -Alopecia

0

1 (1)

1 (1)

   -Fatigue

2 (3)

4 (5)

6 (9)

  1. * P < 0.05 compared with Group A1.