Table 4 Multivariate analysis of factor associated with advanced fibrosis

OR (95%CI)

All subjects n = 7395

R2 = 0.22

R2 = 0.20

Age

1.12 (1.10-1.14) <0.0001

1.13 (1.09-1.16) <0.0001

Male gender

4.31 (2.62-7.08) <0.0001

6.36 (2.03-22.1) 0.002

Waist

1.03 (1.01-1.04) 0.0002

1.05 (1.02-1.07) 0.001

Triglycerides¹

1.32 (1.21-1.45) <0.0001

1.22 (1.07-1.39) 0.001

Total cholesterol

0.61 (0.52-0.72) 0.04

0.81 (0.60-1.11) 0.19

Fasting glucose

1.15 (1.05-1.26) 0.002

1.11 (0.94-1.32) 0.21

Reported alcohol

1.00 (0.99-1.01)

0.99 (0.97-1.01) 0.33

CDT assays ¹ n = 1076

R2 = 0.31

R2 = 0.31

CDT

2.09 (1.42-3.05) 0.0002

2.11 (1.39-3.20) 0.0005

CDT assays and HCV antibody ¹ testing n = 500

R2 = 0.35

R2 = 0.36

CDT

1.82 (1.21-2.73) 0.004

1.78 (1.24-2.56) 0.01

HCV positive

18.0 (2.43-132.7) 0.005

26.8 (2.75-261.3) 0.005