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Table 3 Distribution of risk factors, genotypes of NOS2 polymorphisms Ser608Leu and -954G/C, and odds ratios (OR) for gastric adenocarcinoma (GA), chronic gastritis (CG), and control (C) groups.

From: Gastric cancer is associated with NOS2-954G/C polymorphism and environmental factors in a Brazilian population

Variables

 

GA × C

 

CG × C

 

GA/C

N

OR (95%CI)

p

CG/C

N

OR (95%CI)

p

Gender

      

Female

36/78

Reference

 

82/78

Reference

 

Male

114/86

1.79 (1.02-3.15)

0.04

78/86

0.52 (0.31-0.88)

0.01

Age

      

<57 years

42/96

Reference

 

91/96

Reference

 

≥57 years

108/68

2.94 (1.77-4.90)

<0.01

69/68

1.03 (0.64-1.65)

0.88

Smoking

      

Nonsmokers

43/103

Reference

 

73/103

Reference

 

Smokers

107/61

2.68 (1.58-4.53)

<0.01

87/61

1.93 (1.19-3.13)

<0.01

Alcohol

      

Nondrinkers

65/132

Reference

 

100/132

Reference

 

Drinkers

85/32

3.60 (2.05-6.32)

<0.01

60/32

2.79 (1.55-5.02)

<0.01

Ser608Leu

      

CC

106/111

Reference

 

108/111

Reference

 

CT+TT

44/53

1.19 (0.69-2.08)

0.51

52/53

1.12 (0.68-1.83)

0.64

-954G/C

      

GG

77/112

Reference

 

116/112

Reference

 

GC+CC

73/52

1.87 (1.12-3.13)

0.01

44/52

0.83 (0.50-1.38)

0.48

  1. N, Number of individuals; OR, Odds Ratio; CI, Confidence Interval; P, probability.