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Table 1 Liver function test and histologic features pre- and post-prednisone

From: Autoimmune enteropathy with a CD8+ CD7-T-cell small bowel intraepithelial lymphocytosis: case report and literature review

 

Pre-prednisone

Post-prednisone

 

Presentation

15 months

21 months

26 months

Liver Function Tests

AST (U/L)

107

43

41

65

ALT (U/L)

95

46

97

82

ALP (U/L)

240

205

110

123

Albumin (g/dL)

2.2

1.5

2.1

3.5

Histology

Histology

IEL

Intact villi

Chronic inflammation

Intact villi

Duodenum + jejunum+ illeum: lymphoplastic infiltrate

Colon + cecum + rectum:

lymphoplastic infiltrate

IEL

Subtotal villous atrophy

IEL

Subtotal villous atrophy Segmental areas normal

Immuno-phenotype

not obtained

Jejunum + illeum: CD3 + CD5 + CD8 + CD7 - preponderance

Jejunum: Polyclonal αβTCR + CD3 + preponderance

CD8 + CD25 - CD7 - (70% of total IEL)

Jejunum: Polyclonal αβTCR + CD3 + (94% of total IEL) CD8 + CD25 - CD7 - (41% of CD3 + fraction)