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Table 3 Discrepancy against a diagnostic reference.

From: Comparison of accuracy of fibrosis degree classifications by liver biopsy and non-invasive tests in chronic hepatitis C

 

Discrepancy score

Significant discrepancies (%)

Population #

1a

2

3

4

1a

2

3

4

Local pathologist

0.40 ± 0.58

-

-

-

4.9

-

-

-

Expert pathologist

0.17 ± 0.38

-

-

-

0.0

-

-

-

Fibrotest

0.86 ± 0.77

0.84 ± 0.80

0.86 ± 0.93

0.92 ± 0.82

17.2

18.2

21.3

22.2

FibroMeter2G

0.30 ± 0.58

0.30 ± 0.55

0.36 ± 0.62

0.38 ± 0.61

5.6

4.6

5.7

6.0

FibroMeter3G

0.11 ± 0.33

0.14 ± 0.37

0.23 ± 0.44

0.17 ± 0.40

0.5

0.7

0.9

0.9

Fibroscan

-

-

0.50 ± 0.79

0.64 ± 0.74

-

-

12.9

12.3

p b

< 10-3

< 10-3

< 10-3

< 10-3

< 10-3

< 10-3

< 10-3

< 10-3

  1. Discrepancy score and significant discrepancies (≥ 2 FM stages) with liver biopsy results as a function of fibrosis classifications by pathologists, blood tests or Fibroscan according to the 4 populations.
  2. a The reference is consensus reading of liver biopsy
  3. b by paired Cochran or Friedman test