Skip to main content

Table 5 Diagnostic accuracy of the ALP, bilirubin, albumin, platelet count and fibrosis-cirrhosis index (FCI) for the prediction of F0-F1 stage and hepatic cirrhosis in chronic HCV infected patients (n = 157)

From: A comparison of four fibrosis indexes in chronic HCV: Development of new fibrosis-cirrhosis index (FCI)

Marker Cutoff

Interpretation

AUC [95% CI]

Spe%

Sen%

PPV%

NPV%

ALP

< 120

F0-F1 (n = 68)

F2-F4 (n = 89)

0.829 [0.760-0.897]

69.6

85.2

68.2

86.1

 

58/10

27/62

     

> 240

F4 (n = 21)

F0-F3 (n = 136)

0.931 [0.882-0.981]

91.9

80.9

60.7

96.9

 

17/4

11/125

     

Bilirubin

< 0.95

F0-F1 (n = 68)

F2-F4 (n = 89)

0.729 [0.643-0.815]

68.1

85.2

67.4

85.7

 

58/10

28/60

     

> 1.5

F4 (n = 21)

F0-F3 (n = 136)

0.889 [0.816-0.962]

95.5

66.6

70

94.8

 

14/7

6/130

     

Albumin

> 4.1

F0-F1 (n = 68)

F2-F4 (n = 89)

0.812 [0.738-0.886]

67.4

100

70.1

100

 

68/0

29/60

     

< 3.85

F4 (n = 21)

F0-F3 (n = 136)

0.879 [0.796-0.962]

92.6

71.4

60

95.4

 

15/6

10/126

     

Platelet count

> 150

F0-F1 (n = 68)

F2-F4 (n = 89)

0.935[0.900-0.970]

69.6

98.5

71.2

98.4

 

67/1

27/62

     

< 100

F4 (n = 21)

F0-F3 (n = 136)

0.990[0.977-1.002]

98.5

80.9

89.4

97.1

 

17/4

2/134

     

FCI

< 0.130

F0-F1 (n = 68)

F2-F4 (n = 89)

0.932[0.895-0.969]

86.5

80.8

82.1

85.5

 

55/13

12/77

     

> 1.25

F4 (n = 21)

F0-F3 (n = 136)

0.996[0.989-1.002]

100

85.7

100

97.8

 

18/3

0/136

     
  1. Spearman rank correlation coefficient (R-index) for ALP = 0.716, bilirubin = 0.597, albumin = -0.700, platelet count = -0.817 and FCI = 0.818.