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Table 3 Performance characteristics of anti-GP2 and ASCA IgA/IgG and PAB investigating 169 CD patients and 102 UC patients

From: Pancreatic-specific autoantibodies to glycoprotein 2 mirror disease location and behaviour in younger patients with Crohn’s disease

 

sensitivity

95% CI

specificity

95% CI

+LR

95% CI

-LR

95% CI

anti-GP2 IgA

13.0

8.3–19.0

98.0

93.0–99.8

6.6

1.6–27.4

0.9

0.8–1.0

anti-GP2 IgG

28.4

21.7–35.8

92.2

85.1–96.6

3.6

1.8–7.3

0.8

0.7–0.9

anti-GP2 IgA or IgG

30.2

23.4–37.7

91.2

83.9–95.9

3.4

1.8–6.6

0.8

0.7–0.9

ASCA IgA

23.1

17.0–30.2

97.1

91.6–99.4

7.8

2.5–24.7

0.8

0.7–0.9

ASCA IgG

28.4

21.7–35.8

95.1

88.9–98.4

5.8

2.4–14.1

0.8

0.7–0.8

ASCA IgA or IgG

35.5

28.3–43.2

93.1

86.4–97.2

5.2

2.5–10.9

0.7

0.6–0.8

PAB ≥1/20

45.4

37.6–53.4

76.5

67.0–84.3

1.9

1.3–2.8

0.7

0.6–0.8

PAB ≥1/40

38.5

31.1–46.2

79.4

70.3–86.8

1.9

1.2–2.9

0.8

0.7–0.9

at least 1 ab*

50.9

43.1–58.6

85.3

76.9–91.5

3.5

2.1–5.6

0.6

0.5–0.7

at least 2 ab*

27.2

20.7–34.6

97.1

91.6–99.4

9.2

3.0–29.0

0.8

0.7–0.8

at least 3 ab*

10.6

6.4–16.3

100.0

96.4–100.0

 

0.9

0.8–0.9

at least 4 ab*

4.1

1.7–8.3

100.0

96.4–100.0

 

1.0

0.1–1.0

  1. Sensitivity, specificity and likelihood ratios were calculated using a cut-off of 20 U/ml for all ELISA and a titre of 1/20 and 1/40 of IIF.
  2. ab, antibody; ASCA, antibody to mannan of Saccharomyces cerevisiae; CD, Crohn’s disease; CI, confidence interval; ELISA, enzyme-linked immunosorbent assay; GP2, zymogen granule membrane glycoprotein 2; LR, likelihood ratio; PAB, pancreatic autoantibody; UC, ulcerative colitis; *anti GP2 and/ or ASCA.