Table 1 Demographic, clinical, histological, metabolic features, and PNPLA3 I148M genotype of NAFLD and CHC patients, and healthy controls with very low probability of steatosis
NAFLD patients (n = 144) | CHC patients (n = 261) | Healthy controls (n = 257) | |
|---|---|---|---|
Sex (F) | 32 (22%) | 110^ (42%) | 55 (21%) |
Age (years) | 49.5±12 | 58.1±14^ | 48±12 |
BMI (Kg/m2) | 26.8±3.3^ | 25.4±3.9 | 25.0±2.8 |
Ferritin (ng/ml) | 470±420^ | 248±372^ | 52±47 |
Total cholesterol (mg/dl) | 206±40 | 178±38^ | 193±33 |
HDL cholesterol (mg/dl) | 47±13^ | 50±17^ | 57±13 |
Triglycerides (mg/dl) | 133±64^ | 105±50^ | 88±46 |
Glucose (mg/dl) | 98±27^ | 95±23^ | 67±39 |
Diabetes | 17 (12%)^ | 47 (18%)^ | 0 |
ALT (IU/ml) | 60±46^ | 70±59^ | 22±9 |
GGT (IU/ml) | 87±122^ | 61±69^ | 21±13 |
Steatosis | 144 (100)^ | 179 (69)^ | 0 |
Steatosis 2-3 | 41* (36)^ | 23 (9)^ | 0 |
NASH | 52* (45) | NA | NA |
Fibrosis | 60* (52) | 258 (99) | NA |
Cirrhosis | 0 | 80 (31)^ | 0 |
FFAs (mmol/l)° | 0.22 ± 0.01^ | NA | 0.16±0.01 |
Insulin (IU/ml)° | 14.3 {10.8-20}^ | NA | 11.7 {9.2-14.5}^ |
HOMA-IR° | 3.2 {2.5-4.8}^ | NA | 2.5 {1.9-3.2} |
Adipo-IR° | 14.9±14.5^ | NA | 6.1±2.7 |
Adiponectin (μg/ml) | 4.9 {3.0-7.8}^ | 9.4 {5.7-13.3}^ | 6.6 {4.7-9.3} |
ADIPOQ | |||
rs2241766TT and rs1501299T+ | 83 (57) | 143 (55) | 142 (55) |
rs2241766G + or rs1501299GG | 61 (43) | 118 (45) | 115 (45) |
PNPLA3 rs738409 | |||
CC (148 I/I) | 55 (38) | 133 (51) | 146 (57) |
CG (148 I/M) | 68 (47) | 103 (39) | 95 (37) |
GG (148 M/M) | 21 (15) | 25 (10) | 16 (6) |