Table 6 Clinical features of 261 CHC patients from Northern Italy according to the PNPLA3 I148M genotype
PNPLA3genotype | CC n = 133 (51) | CG n = 103 (39) | GG n = 25 (10) | p value |
|---|---|---|---|---|
Age (years) | 57±14 | 59±14 | 57±14 | 0.47 |
Sex (F) | 58 (44) | 46 (45) | 6 (24) | 0.16 |
BMI (Kg/m2) | 25.2±3.4 | 25.3±3.9 | 26.6±6.1 | 0.25 |
ALT (IU/ml) | 72±56 | 67±58 | 73±78 | 0.81 |
Diabetes | 26 (20) | 17 (17) | 4 (16) | 0.80 |
Insulin (IU/ml) | 21 {14–27} | 20 {17–27} | 17 {12–25} | 0.61 |
Glucose | 95±22 | 96±26 | 93±22 | 0.85 |
Total cholesterol (mg/dl) | 176±36 | 177±41 | 178±41 | 0.95 |
HDL cholesterol (mg/dl) | 50±15 | 51±18 | 48±15 | 0.66 |
Triglycerides (mg/dl) | 108±43 | 104±61 | 88±31* | 0.24 |
HOMA-IR | 4.7 {3.2-5.8} | 4.5 {3.4-6.6} | 3.8 {2.3-6.5} | 0.62 |
Adiponectin (μg/ml) | 9.3 {5.8-13} | 9.4 {5.7-14} | 9.7 {5.3-13} | 0.93 |
Steatosis | 85 (64) | 72 (70) | 22 (88) | 0.02 |
Severe steatosis (> 33%) | 8 (6) | 7 (7) | 8 (32) | <0.0001 |
Cirrhosis | 34 (26) | 36 (35) | 10 (40) | 0.06 |