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Figure 2 | BMC Gastroenterology

Figure 2

From: Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia, phosphorylation of NMDA receptors, and cytokines expression in the thoracic spinal dorsal horn

Figure 2

Intrathecal administration of resolvin D 1 (RvD1) attenuates mechanical allodynia induced by CP. (A) Response frequencies to mechanical stimulation of the abdomen with the 40.7 mN of von-Frey filaments at different time points after RvD1 (or vehicle) administration. BL: baseline. (B) Response frequencies to mechanical stimulation of the abdomen with von-Frey filaments of various strengths at 4 h after RvD1 (or vehicle) treatments. *, # P<0.05 compared with that of sham-vehicle or TNBS-vehicle group, respectively. (C) TNBS-induced allodynia was significantly attenuated by RvD1 in a dose-dependent manner. * P<0.05 compared to 100 ng/kg group.

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BMC Gastroenterology

ISSN: 1471-230X

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