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Table 1 Clinical, histological and serological parameters in 59 untreated patients with PBC at time of first diagnosis

From: Analysis of the clinical relevance of antimitochondrial antibodies to the β- and γ-subunits of the F1F0-ATPase in patients with primary biliary cirrhosis

Parameters

Total

Inactive PBC

Active PBC

 

n = 59

n = 37

n = 22

Females (number)

56

36

20

Males (number)

3

1

2

Biochemical parameters: mean + SD (median)

AP (U/l) (normal < 120)

440 + 374 (309)

344 + 250 (235)

647+519 (537)a)

ASAT (U/l) (normal < 35)

38 + 43 (24)

34 + 48 (20)

46 + 28 (43)b)

ALAT (U/l) (normal < 35)

51 + 56 (26)

43 + 53 (25)

62 + 62 (42)

γGT (U/l) (normal < 50)

145 + 107 (129)

128 + 86 (127)

194 + 146 (164)

bilirubin (mg%) (normal < 1.5)

1,4 + 1,8 (1,0)

0,8 + 0,7 (0,9)

2,3 + 2,8 (1,5)b)

IgG-globulins (mg%) (normal < 1800)

1527 + 477 (1450)

1395 + 603 (1310)

1331 + 733 (1450)

IgM-globulins (mg%) (normal < 280)

373 + 201 (324)

298 + 162 (162)

398 + 290 (427)

Histological stages (number):

PBC I/II

45

37

8

PBC III/IV

14

0

14

Autoantibodies to: number (%)

mitochondria (IFT)

54 (92)

33 (89)

21 (95)

M2 (ELISA)

51 (86)

31 (84)

20 (91)

nuclear dots (sp100; IFT)

14 (24)

9 (24)

5 (23)

nuclear membrane (gp210; IFT)

4 (7)

1 (3)

3 (14)

centromeres

6 (10)

2 (5)

3 (14)

  1. Significance between patients with inactive and active PBC: a) trend with p = 0.08; b) p < 0.05.