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Table 5 Genotype frequencies of GNB1 single nucleotide polymorphisms stratified by gender in HCV-1 and HCV-2 infected patients receiving PEG-IFNα-RBV therapy with and without a RVR in a Chinese population in Taiwan

From: Association of genetic variations in GNB1 with response to peginterferon plus ribavirin therapy for chronic hepatitis C in a Chinese population in Taiwan

HCV-1

HCV-2

SNP ID

RVR (+) N (%)

RVR (−) N (%)

Pvalue

OR (95% CI)

SNP ID

RVR (+) N (%)

RVR (−) N (%)

Pvalue

OR (95% CI)

rs10907185

rs10907185

 

Males

Males

A/A

6 (10.9)

2 (2.8)

 

4.32 (0.81, 23.17)

A/A

8 (10.7)

0 (0.0)

 

-

A/G

24 (43.6)

36 (48.6)

 

0.96 (0.46, 1.98)

A/G

27 (36.0)

6 (46.2)

 

0.79 (0.24, 2.60)

G/G

25 (45.5)

36 (48.6)

0.1600

1

G/G

40 (53.3)

7 (53.8)

0.4292

1

A/A + A/G

30 (54.5)

38 (51.4)

0.7193

1.14 (0.56, 2.29)

A/A + A/G

35 (46.7)

6 (46.2)

0.9727

1.02 (0.31, 3.33)

Females

Females

A/A

4 (7.6)

3 (3.6)

 

2.19 (0.46, 10.52)

A/A

5 (6.0)

3 (12.5)

 

0.66 (0.14, 3.07)

A/G

21 (39.6)

34 (41.0)

 

1.01 (0.49, 2.08)

A/G

35 (42.2)

4 (16.7)

 

3.46 (1.07, 11.22)

G/G

28 (52.8)

46 (55.4)

0.5986

1

G/G

43 (51.8)

17 (70.8)

0.0618

1

A/A + A/G

25 (47.2)

37 (44.6)

0.7673

1.11 (0.56, 2.22)

A/A + A/G

40 (48.2)

7 (29.2)

0.0981

2.26 (0.85, 6.02)

rs6603797

rs6603797

 

Males

Males

C/C

45 (81.8)

50 (67.6)

 

-

C/C

60 (80.0)

12 (92.3)

 

-

C/T

9 (16.4)

24 (32.4)

 

-

C/T

15 (20.0)

1 (7.7)

 

-

T/T

1 (1.8)

0 (0.0)

0.0672

1

T/T

0 (0.0)

0 (0.0)

-

1

C/C + C/T

54 (98.2)

74 (100.0)

0.2442

-

C/C + C/T

75 (100.0)

13 (100.0)

-

-

Females

Females

C/C

42 (79.2)

66 (79.5)

 

1.91 (0.19, 18.97)

C/C

69 (83.1)

19 (79.2)

 

1.82 (0.16, 21.12)

C/T

10 (18.9)

14 (16.9)

 

2.14 (0.19, 23.72)

C/T

12 (14.5)

4 (16.6)

 

1.50 (0.11, 21.31)

T/T

1 (1.9)

3 (3.6)

0.8179

1

T/T

2 (2.4)

1 (4.2)

0.8601

1

C/C + C/T

52 (98.1)

80 (96.4)

0.5609

1.95 (0.20, 19.26)

C/C + C/T

81 (97.6)

23 (95.8)

0.6461

1.76 (0.15, 20.30)

rs4648727

rs4648727

 

Males

Males a

A/A

4 (7.3)

5 (6.8)

 

1.20 (0.29, 5.02)

A/A

9 (12.0)

0 (0.0)

 

-

A/C

31 (56.4)

39 (52.7)

 

1.19 (0.57, 2.49)

A/C

39 (52.0)

5 (41.7)

 

2.02 (0.58, 7.05)

C/C

20 (36.3)

30 (40.5)

0.8905

1

C/C

27 (36.0)

7 (58.3)

0.2255

1

A/A + A/C

35 (63.6)

44 (59.5)

0.6301

1.19 (0.58, 2.45)

A/A + A/C

48 (64.0)

5 (41.7)

0.1410

2.49 (0.72, 8.61)

Females a

Females

A/A

6 (11.4)

9 (11.0)

 

0.79 (0.25, 2.48)

A/A

7 (8.4)

4 (16.7)

 

0.78 (0.20, 3.04)

A/C

19 (35.8)

40 (48.8)

 

0.56 (0.27, 1.18)

A/C

40 (48.2)

4 (16.7)

 

4.44 (1.36, 14.53)

C/C

28 (52.8)

33 (40.2)

0.3067

1

C/C

36 (43.4)

16 (66.6)

0.0202*

1

A/A + A/C

25 (47.2)

49 (59.8)

0.1513

0.60 (0.30, 1.21)

A/A + A/C

47 (56.6)

8 (33.3)

0.0443*

2.61 (1.01, 6.77)

rs12126768

rs12126768

 

Males

Males

G/G

3 (5.5)

3 (4.1)

 

1.06 (0.20, 5.59)

G/G

2 (2.7)

0 (0.0)

 

-

G/T

17 (30.9)

34 (45.9)

 

0.53 (0.25, 1.11)

G/T

31 (41.3)

4 (30.8)

 

1.66 (0.47, 5.89)

T/T

35 (63.6)

37 (50.0)

0.2244

1

T/T

42 (56.0)

9 (69.2)

0.6089

1

G/G + G/T

20 (36.4)

37 (50.0)

0.1230

0.57 (0.28, 1.17)

G/G + G/T

33 (44.0)

4 (30.8)

0.3723

1.77 (0.50, 6.25)

Females a

Females

G/G

3 (5.7)

6 (7.3)

 

0.62 (0.14, 2.65)

G/G

4 (4.8)

4 (16.7)

 

0.34 (0.08, 1.52)

G/T

16 (30.2)

34 (41.5)

 

0.58 (0.28, 1.23)

G/T

32 (38.6)

4 (16.7)

 

2.72 (0.83, 8.90)

T/T

34 (64.1)

42 (51.2)

0.3339

1

T/T

47 (56.6)

16 (66.6)

0.0350*

1

G/G + G/T

19 (35.8)

40 (48.8)

0.1391

0.59 (0.29, 1.19)

G/G + G/T

36 (43.4)

8 (33.4)

0.3786

1.53 (0.59, 3.97)

  1. a: Contains 1 missing data point in the RVR (−) group.
  2. Abbreviations: SNP, single nucleotide polymorphism; RVR, rapid virological response; OR, odds ratio; CI, confidence interval.
  3. Genotype frequencies were determined by χ 2 test using 2 × 3 or 2 × 2 tables as appropriate. Odds ratios and 95% CI per genotype were estimated by unconditional logistic regression. P values less than 0.05 were considered statistically significant, and are denoted with an asterisk.