Table 6 Allele frequencies of GNB1 single nucleotide polymorphisms stratified by gender in HCV-1- and HCV-2-infected patients receiving PEG-IFNα-RBV therapy with and without RVR in a Chinese population in Taiwan
HCV-1 | HCV-2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
SNP ID | RVR (+) N (%) | RVR (−) N (%) | Pvalue | OR (95% CI) | SNP ID | RVR (+) N (%) | RVR (−) N (%) | Pvalue | OR (95% CI) |
Males | |||||||||
rs10907185 | rs10907185 | ||||||||
A allele | 36 (32.7) | 40 (27.0) | 1.31 (0.77, 2.25) | A allele | 43 (28.7) | 6 (23.1) | 1.34 (0.50, 3.56) | ||
G allele | 74 (67.3) | 108 (73.0) | 0.3206 | 1 | G allele | 107 (71.3) | 20 (76.9) | 0.5572 | 1 |
rs6603797 | rs6603797 | ||||||||
C allele | 99 (90.0) | 124 (83.8) | 1.74 (0.81, 3.73) | C allele | 135 (90.0) | 25 (96.2) | 0.36 (0.05, 2.85) | ||
T allele | 11 (10.0) | 24 (16.2) | 0.1493 | 1 | T allele | 15 (10.0) | 1 (3.8) | 0.3136 | 1 |
rs4648727 | rs4648727 a | ||||||||
A allele | 39 (35.5) | 49 (33.1) | 1.11 (0.66, 1.87) | A allele | 57 (38.0) | 5 (20.8) | 2.33 (0.82, 6.58) | ||
C allele | 71 (64.5) | 99 (66.9) | 0.6942 | 1 | C allele | 93 (62.0) | 19 (79.2) | 0.1030 | 1 |
rs12126768 | rs12126768 | ||||||||
G allele | 23 (20.9) | 40 (27.0) | 0.71 (0.40, 1.28) | G allele | 35 (23.3) | 4 (15.4) | 1.67 (0.54, 5.18) | ||
T allele | 87 (79.1) | 108 (73.0) | 0.2580 | 1 | T allele | 115 (76.7) | 22 (84.6) | 0.3676 | 1 |
Females | |||||||||
rs10907185 | rs10907185 | ||||||||
A allele | 29 (27.4) | 40 (24.1) | 1.19 (0.68, 2.07) | A allele | 45 (27.1) | 10 (20.8) | 1.41 (0.65, 3.07) | ||
G allele | 77 (72.6) | 126 (75.9) | 0.5465 | 1 | G allele | 121 (72.9) | 38 (79.2) | 0.3809 | 1 |
rs6603797 | rs6603797 | ||||||||
C allele | 94 (88.7) | 146 (88.0) | 1.07 (0.50, 2.30) | C allele | 150 (90.4) | 42 (87.5) | 1.34 (0.49, 3.64) | ||
T allele | 12 (11.3) | 20 (12.0) | 0.8559 | 1 | T allele | 16 (9.6) | 6 (12.5) | 0.5653 | 1 |
rs4648727 a | rs4648727 | ||||||||
A allele | 31 (29.2) | 58 (35.4) | 0.76 (0.45, 1.28) | A allele | 54 (32.5) | 12 (25.0) | 1.45 (0.70, 3.00) | ||
C allele | 75 (70.8) | 106 (64.6) | 0.2961 | 1 | C allele | 112 (67.5) | 36 (75.0) | 0.3198 | 1 |
rs12126768 a | rs12126768 | ||||||||
G allele | 22 (20.8) | 46 (28.0) | 0.67 (0.38, 1.20) | G allele | 40 (24.1) | 12 (25.0) | 0.95 (0.45, 2.00) | ||
T allele | 84 (79.2) | 118 (72.0) | 0.1776 | 1 | T allele | 126 (75.9) | 36 (75.0) | 0.8977 | 1 |