From: Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
 | Total (n = 576) | Fibrosis stage 0-2 (n = 512) | Fibrosis stage 3-4 (n = 64) | p-value b |
---|---|---|---|---|
Age (yr) | 52.3 ± 15.4 | 51.2 ± 15.5 | 62.0 ± 10.1 | < 0.0001 |
Gender (female) | 280 (49%) | 235 (46%) | 45 (70%) | 0.0003 |
BMI (kg/m 2 ) | 27.9 ± 4.9 | 27.8 ± 4.9 | 28.6 ± 4.8 | 0.2138 |
Obesity (BMI > 25) | 418 (73%) | 369 (72%) | 49 (77%) | 0.5524 |
Hypertension (yes) | 184 (32%) | 150 (29%) | 34 (53%) | 0.0062 |
Type 2 diabetes (yes) | 241 (42%) | 199 (39%) | 42 (66%) | 0.0001 |
Hemoglobin (g/dL) | 14.6 ± 2.0 | 14.7 ± 2.0 | 13.7 ± 2.0 | 0.0001 |
Platelet count (×10 9 /L) | 227 ± 67 | 235 ± 64 | 162 ± 52 | < 0.0001 |
AST (IU/L) | 43 (30-67) | 41 (29-64) | 61 (47-77) | < 0.0001 |
ALT (IU/L) | 69 (43-112) | 69 (43-69) | 62 (46-94) | 0.5074 |
AST/ALT ratio | 0.65 (0.52-0.82) | 0.63 (0.51-0.78) | 0.98 (0.73-1.21) | < 0.0001 |
GGT (IU/L) | 60 (39-99) (n = 572) | 57 (36-92) (n = 508) | 84 (59-128) | < 0.0001 |
Albumin (g/dL) | 4.4 ± 0.4 | 4.4 ± 0.4 | 4.1 ± 0.4 | < 0.0001 |
Cholinesterase (IU/L) | 380 (330-433) (n = 527) | 385 (337-439) (n = 466) | 297 (244-367) (n = 61) | < 0.0001 |
Total cholesterol (mg/dL) | 209 ± 40 (n = 467) | 210 ± 39 (n = 409) | 198 ± 42 (n = 58) | 0.0484 |
Triglyceride (mg/dL) | 147 (107-207) (n = 566) | 150 (109-212) (n = 502) | 131 (95-184) (n = 64) | 0.0364 |
HDL-C (mg/dL) | 50 ± 17 (n = 548) | 50 ± 17 (n = 487) | 51 ± 13 (n = 61) | 0.7516 |
LDL-C (mg/dL) | 128 ± 33 (n = 405) | 129 ± 32 (n = 363) | 120 ± 42 (n = 42) | 0.1666 |
Ferritin (ng/mL) | 173 (92-300) | 169 (91-292) | 216 (128-349) | 0.0627 |
FPG (mg/dL) | 103 (94-122) (n = 524) | 103 (94-119) (n = 462) | 111 (95-138) (n = 62) | 0.0166 |
IRI (μU/mL) | 11.6 (7.8-18.4) | 11.3 (7.5-17.4) | 17.3 (11.3-26.2) | < 0.0001 |
FIB4 index | 1.23 (0.77-2.02) | 1.13 (0.71-1.79) | 3.17 (1.88-4.25) | < 0.0001 |
AST/ALT ratio (AAR) | 0.65 (0.52-0.82) | 0.63 (0.51-0.78) | 0.98 (0.73-1.21) | < 0.0001 |
AST to platelet ratio index (APRI) | 0.61 (0.40-0.98) | 0.57 (0.38-0.92) | 1.22 (0.86-1.79) | < 0.0001 |
Age-platelet index (AP index) | 4 (2-6) | 3 (2-5) | 7 (5-8) | < 0.0001 |
NAFLD fibrosis score | -1.82 (-3.04 to -0.58) | -2.07 (-3.25 to -0.95) | 0.25 (-0.60-1.06) | < 0.0001 |
BARD score | Â | Â | Â | < 0.0001 |
   0 | 144 (25%) | 138 (27%) | 6 (9%) |  |
   1 | 201 (35%) | 194 (38%) | 7 (11%) |  |
   2 | 112 (19%) | 99 (19%) | 13 (20%) |  |
   3 | 88 (15%) | 62 (12%) | 26 (41%) |  |
   4 | 31 (5%) | 19 (4%) | 12 (19%) |  |
N score | Â | Â | Â | < 0.0001 |
   0 | 135 (23%) | 135 (26%) | 0 (0%) |  |
   1 | 170 (30%) | 157 (31%) | 13 (20%) |  |
   2 | 118 (20%) | 96 (19%) | 22 (34%) |  |
   3 | 99 (17%) | 82 (16%) | 17 (27%) |  |
   4 | 54 (9%) | 42 (8%) | 12 (19%) |  |