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Table 2 Characteristics of study population and values of noninvasive fibrosis marker panelsa.

From: Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population

 

Total

(n = 576)

Fibrosis stage 0-2 (n = 512)

Fibrosis stage 3-4 (n = 64)

p-value b

Age (yr)

52.3 ± 15.4

51.2 ± 15.5

62.0 ± 10.1

< 0.0001

Gender (female)

280 (49%)

235 (46%)

45 (70%)

0.0003

BMI (kg/m 2 )

27.9 ± 4.9

27.8 ± 4.9

28.6 ± 4.8

0.2138

Obesity (BMI > 25)

418 (73%)

369 (72%)

49 (77%)

0.5524

Hypertension (yes)

184 (32%)

150 (29%)

34 (53%)

0.0062

Type 2 diabetes (yes)

241 (42%)

199 (39%)

42 (66%)

0.0001

Hemoglobin (g/dL)

14.6 ± 2.0

14.7 ± 2.0

13.7 ± 2.0

0.0001

Platelet count (×10 9 /L)

227 ± 67

235 ± 64

162 ± 52

< 0.0001

AST (IU/L)

43 (30-67)

41 (29-64)

61 (47-77)

< 0.0001

ALT (IU/L)

69 (43-112)

69 (43-69)

62 (46-94)

0.5074

AST/ALT ratio

0.65 (0.52-0.82)

0.63 (0.51-0.78)

0.98 (0.73-1.21)

< 0.0001

GGT (IU/L)

60 (39-99)

(n = 572)

57 (36-92)

(n = 508)

84 (59-128)

< 0.0001

Albumin (g/dL)

4.4 ± 0.4

4.4 ± 0.4

4.1 ± 0.4

< 0.0001

Cholinesterase (IU/L)

380 (330-433)

(n = 527)

385 (337-439)

(n = 466)

297 (244-367)

(n = 61)

< 0.0001

Total cholesterol (mg/dL)

209 ± 40

(n = 467)

210 ± 39

(n = 409)

198 ± 42

(n = 58)

0.0484

Triglyceride (mg/dL)

147 (107-207)

(n = 566)

150 (109-212)

(n = 502)

131 (95-184)

(n = 64)

0.0364

HDL-C (mg/dL)

50 ± 17

(n = 548)

50 ± 17

(n = 487)

51 ± 13

(n = 61)

0.7516

LDL-C (mg/dL)

128 ± 33

(n = 405)

129 ± 32

(n = 363)

120 ± 42

(n = 42)

0.1666

Ferritin (ng/mL)

173 (92-300)

169 (91-292)

216 (128-349)

0.0627

FPG (mg/dL)

103 (94-122)

(n = 524)

103 (94-119)

(n = 462)

111 (95-138)

(n = 62)

0.0166

IRI (μU/mL)

11.6 (7.8-18.4)

11.3 (7.5-17.4)

17.3 (11.3-26.2)

< 0.0001

FIB4 index

1.23 (0.77-2.02)

1.13 (0.71-1.79)

3.17 (1.88-4.25)

< 0.0001

AST/ALT ratio

(AAR)

0.65 (0.52-0.82)

0.63 (0.51-0.78)

0.98 (0.73-1.21)

< 0.0001

AST to platelet ratio index (APRI)

0.61 (0.40-0.98)

0.57 (0.38-0.92)

1.22 (0.86-1.79)

< 0.0001

Age-platelet index (AP index)

4 (2-6)

3 (2-5)

7 (5-8)

< 0.0001

NAFLD fibrosis score

-1.82

(-3.04 to -0.58)

-2.07

(-3.25 to -0.95)

0.25

(-0.60-1.06)

< 0.0001

BARD score

   

< 0.0001

   0

144 (25%)

138 (27%)

6 (9%)

 

   1

201 (35%)

194 (38%)

7 (11%)

 

   2

112 (19%)

99 (19%)

13 (20%)

 

   3

88 (15%)

62 (12%)

26 (41%)

 

   4

31 (5%)

19 (4%)

12 (19%)

 

N score

   

< 0.0001

   0

135 (23%)

135 (26%)

0 (0%)

 

   1

170 (30%)

157 (31%)

13 (20%)

 

   2

118 (20%)

96 (19%)

22 (34%)

 

   3

99 (17%)

82 (16%)

17 (27%)

 

   4

54 (9%)

42 (8%)

12 (19%)

 
  1. BMI, body mass index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ-glutamyl transpeptidase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FPG, fasting plasma glucose; and IRI, immuno-reactive insulin. a Values are mean ± SD, median (interquartile range), counts (%), as appropriate. bValues from univariate ordinal logistic regression, Mann-Whitney, or χ2 analysis, as appropriate.