Table 1 Characteristics of the subjects and the PTPN11 polymorphisms
| Â | Gastric cancer (%) | Gastric atrophy (%) | Control(%) | P value (%) |
|---|---|---|---|---|
N | 414 | 109 | 923 | Â |
Sex | Â | Â | Â | Â |
Male | 300(72.5) | 64(58.7) | 539(58.4) | <0.001 |
Female | 114(27.5) | 45(41.3) | 384(41.6) | Â |
Age | Â | Â | Â | Â |
≤45 | 32(7.7) | 19(17.4) | 276(29.9) | <0.001 |
46-65 | 224(54.1) | 80(73.4) | 579(62.7) | Â |
>65 | 158(38.2) | 10(9.2) | 68(7.4) | Â |
Anti-H.pylori IgG | Â | Â | Â | Â |
Negative | 123(29.7) | 27(24.8) | 464(50.3) | <0.001 |
Postive | 291(70.3) | 82(75.2) | 459(49.7) | Â |
SNPs | Â | Â | Â | Â |
rs2301756 | Â | Â | Â | Â |
GG | 305(73.7) | 86(78.9) | 687(74.4) | 0.462 |
GA | 95(22.9) | 22(20.2) | 216(23.4) | Â |
AA | 14(3.4) | 1(0.9) | 20(2.2) | Â |
rs12423190 | Â | Â | Â | Â |
TT | 214(51.7) | 55(50.5) | 476(51.6) | 0.047 |
TC | 166(40.1) | 36(33.0) | 373(40.4) | Â |
CC | 34(8.2) | 18(16.5) | 74(8.0) | Â |
rs12229892 | Â | Â | Â | Â |
GG | 137(33.1) | 40(36.7) | 308(33.4) | 0.963 |
GA | 205(49.5) | 50(45.9) | 454(49.2) | Â |
AA | 72(17.4) | 19(17.4) | 161(17.4) | Â |
rs7958372 | Â | Â | Â | Â |
TT | 305(73.7) | 87(79.8) | 685(74.2) | 0.747 |
TC | 102(24.6) | 21(19.3) | 222(24.1) | Â |
CC | 7(1.7) | 1(0.9) | 16(1.7) | Â |
rs4767860 | Â | Â | Â | Â |
AA | 137(33.1) | 39(35.8) | 306(33.2) | 0.386 |
AG | 206(49.8) | 44(40.4) | 453(49.1) | Â |
GG | 71(17.1) | 26(23.9) | 164(17.8) | Â |