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Table 2 PTPN11 polymorphisms among H. pylori (+) subjects

From: Association of polymorphism of PTPN 11 encoding SHP-2 with gastric atrophy but not gastric cancer in Helicobacter pylori seropositive Chinese population

Genotype

Control (%)

Gastric atrophy (%)

OR(95%CI)*

Pvalue

Gastric cancer (%)

OR(95%CI)*

Pvalue

 

n = 459

n = 82

  

n = 291

  

rs2301756

       

GG

74.3

76.8

Reference

 

73.9

Reference

 

GA

23.5

22.0

0.90(0.51-1.59)

0.72

37.9

0.92(0.62-1.35)

0.66

A/A

2.2

1.2

0.51(0.06-4.09)

0.53

3.4

1.26(0.47-3.37)

0.65

rs12423190

       

TT

52.5

50.0

Reference

 

50.9

Reference

 

TC

40.1

34.1

0.93(0.55-1.57)

0.78

41.2

1.18(0.64-2.18)

0.60

CC

7.4

15.9

2.20(1.06-4.55)

0.03

7.9

1.30(0.93-1.83)

0.13

TT/TC

92.6

84.1

Reference

 

92.1

Reference

 

CC

7.4

15.9

2.47(1.13-4.55)

0.02

7.9

1.21(0.89-1.76)

0.15

rs12229892

       

GG

32.2

36.6

Reference

 

30.6

Reference

 

GA

51.2

47.6

0.82(0.49-1.39)

0.46

52.2

1.04(0.72-1.51)

0.82

AA

16.6

15.9

0.86(0.42-1.75)

0.67

17.2

1.02(0.63-1.67)

0.93

rs7958372

       

TT

74.1

78.0

Reference

 

74.2

Reference

 

TC

24.4

20.7

0.80(0.45-1.43)

0.46

24.1

0.94(0.64-1.37)

0.74

CC

1.5

1.2

0.83(0.10-7.01)

0.86

1.7

1.16(0.30-4047)

0.83

rs4767860

       

AA

33.8

34.1

Reference

 

31.9

Reference

 

AG

49.5

40.2

1.54(0.82-2.91)

0.18

51.9

1.04(0.70-1.88)

0.59

GG

16.8

25.6

0.80(0.46-1.38)

0.43

16.2

1.32(0.92-1.90)

0.14

Haplotpe

       

GTATA

41.3

39.6

Reference

 

41.2

Reference

 

GCGTG

26.0

32.3

1.36(0.92-2.02)

0.12

27.6

1.12(0.80-1.57)

0.51

GTGTA

16.0

14.0

0.96(0.58-1.61)

0.89

14.4

1.14(0.88-1.47)

0.32

ATGCG

12.4

11.6

1.03(0.59-1.78)

0.92

13.1

0.96(0.71-1.32)

0.82

Others

4.3

2.5

  

3.7

  
  1. *OR for each genotype and hapolotype were calculated by age and sex adjusted logistic regression model.