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Table 2 Test characteristics of single and double FIT sampling (OC-sensor) for colorectal cancer and advanced adenoma at a cut-off level of 50 ng/ml in asymptomatic, high-risk subjects referred for surveillance colonoscopy

From: Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study

 

Single FIT (n = 1041)

Double FIT (one FIT+) (n = 451)

  
 

CRC§ (n = 5)

Advanced adenoma‡ ( n = 101)

CRC§ (n = 2)

Advanced adenoma‡ (n = 40)

Sensitivity

80%

28%

50%

33%

N

4/5

28/101

1/2

13/40

(CI in %)

(28–99)

(19–38)

(1–99)

(19–49)

Specificity

89%

91%

81%

82%

N

925/1036

852/935

363/449

336/409

(CI in %)

(87–91)

(89–93)

(77–84)

(78–86)

PPV *

3%

24%

1%

15%

N

4/115

28/115

1/87

13/87

(CI in %)

(1–9)

(17–33)

(0,03–6)

(8–24)

NPV†

99,9%

92%

99,7%

93%

N

925/926

853/926

363/364

337/364

(CI in %)

(99–100)

(90–94)

(98–99,9)

(89–95)

  1. * PPV: positive predictive value.
  2. † NPV: negative predictive value.
  3. § CRC: colorectal cancer.
  4. ‡ Advanced adenoma: Adenomas ≥1.0 cm, with any villous features (i.e. tubulovillous or villous adenoma) or high-grade dysplasia.