|  | Indication groups | |||
---|---|---|---|---|---|
 |  | Personal history of adenomas (n = 516) | Personal history of CRC§ (n = 172) | Family history of CRC§ (n = 353) | Total (n = 1041) |
Test characteristics | Positivity rate | 14% | 12% | 7% | 11% |
 | N | 70/516 | 21/172 | 24/353 | 115/1041 |
 | Sensitivity | 32% | 36% | 21% | 30% |
 | N | 19/60 | 8/22 | 5/24 | 32/106 |
 | (CI in %) | (20–45) | (17–59) | (7–42) | (22–40) |
 | Specificity | 89% | 91% | 94% | 91% |
 | N | 405/456 | 137/150 | 310/329 | 852/935 |
 | (CI in %) | (86–92) | (86–95) | (91–96) | (89–93) |
 | PPV * | 27% | 38% | 21% | 28% |
 | N | 19/70 | 8/21 | 5/24 | 32/115 |
 | (CI in %) | (17–39) | (18–62) | (7–42) | (20–37) |
 | NPV†| 91% | 91% | 94% | 92% |
 | N | 405/446 | 137/151 | 310/329 | 852/926 |
 | (CI in %) | (88–93) | (85–95) | (91–96) | (90–94) |