Skip to main content

Table 3 Positivity rates and test characteristics of single FIT sampling for advanced neoplasia‡ in three different indication groups in 1041 asymptomatic, high-risk subjects referred for surveillance colonoscopy

From: Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study

  

Indication groups

  

Personal history of adenomas (n = 516)

Personal history of CRC§ (n = 172)

Family history of CRC§ (n = 353)

Total (n = 1041)

Test characteristics

Positivity rate

14%

12%

7%

11%

 

N

70/516

21/172

24/353

115/1041

 

Sensitivity

32%

36%

21%

30%

 

N

19/60

8/22

5/24

32/106

 

(CI in %)

(20–45)

(17–59)

(7–42)

(22–40)

 

Specificity

89%

91%

94%

91%

 

N

405/456

137/150

310/329

852/935

 

(CI in %)

(86–92)

(86–95)

(91–96)

(89–93)

 

PPV *

27%

38%

21%

28%

 

N

19/70

8/21

5/24

32/115

 

(CI in %)

(17–39)

(18–62)

(7–42)

(20–37)

 

NPV†

91%

91%

94%

92%

 

N

405/446

137/151

310/329

852/926

 

(CI in %)

(88–93)

(85–95)

(91–96)

(90–94)

  1. ‡ Advanced neoplasia is defined as either one or more advanced adenoma(s) or a CRC.
  2. * PPV: positive predictive value.
  3. † NPV: negative predictive value.
  4. § CRC: colorectal cancer.