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Figure 7 | BMC Gastroenterology

Figure 7

From: Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen

Figure 7

Pro-inflammatory gene expression is enhanced in GC-C −/− livers at 4 and 10 days post-infection. Real time RT-PCR was used to assess differences in liver gene expression from naive and infected mice at days 4 and 10 p.i. At day 4, levels of CXCL1, CXCL9, and LBP were increased in liver from GC-C−/− mice. Consistent with the obvious liver damage seen in the GC-C−/− mice at day 10, levels of IL-22, CXCL1, and CXCL9 were significantly elevated. All values are relative to the level in uninfected GC-C+/+ liver. Line represents median value. (**P ≤ 0.005, *P ≤ 0.05, n = 4-10 mice per group; D4, day 4 p.i.; D10, day 10 p.i.).

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