Reference | Year | Inclusion Period | Country | Group | No. of patients | M/F | Mean age (years) | Mean AFP (ng/ml) | Child-Pugh A/B/C | LB N/H/C | Tumor size (cm) | Matching | Not matching | Score |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RCTs | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Wu [14] | 1995 | 1983-1991 | Taiwan | TACE (+) TACE (−) | 24 28 | 23/1 23/5 | 51.8 ± 12.4 53.2 ± 11.5 | ≥ 400 (n = 15) ≥ 400 (n = 16) | 22/2/0 24/4/0 | —/—/14 —/—/12 | 14.3 ± 4.2 14.5 ± 3.3 | 1-3,5-15 | 17 | 2 |
Yamasaki [15] | 1996 | 1987-1989 | Japan | TACE (+) TACE (−) | 50 47 | 50/0 47/0 | 54.9 ± 6.4 57.1 ± 4.9 | — — | — — | —/—/— —/—/— | 3.1 ± 0.8 3.3 ± 0.9 | 1,2,4,9-12 | — | 2 |
Zhou [16] | 2009 | 2001-2003 | China | TACE (+) TACE (−) | 52 56 | 48/4 49/7 | 45.3 ± 9.8 46.8 ± 9.6 | 1244.2 ± 376 1387.5 ± 426 | 44/8/0 54/2/0 | —/—/49 —/—/50 | 9.0 ± 3.2 9.5 ± 3.9 | 1-3,5-10, 12,14,15 | — | 3 |
Kaibori [24] | 2012 | 2004-2007 | Japan | TACE (+) TACE (−) | 42 43 | 35/7 32/11 | 68.1 ± 5.7 66.1 ± 10.6 | 2432 ± 11638 858 ± 5269 | 37/5/0 39/4/0 | 1/27/14 4/28/11 | 4.3 ± 2.1 4.8 ± 4.1 | 1-10,12, 13,15 | 11 | 3 |
NRCTs | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Nagasue [12] | 1989 | 1980-1986 | Japan | TACE (+) TACE (−) | 31 107 | 25/6 90/17 | 56.5 ± 9.1 59.4 ± 8.9 | >20 (n = 18) >20 (n = 76) | 17/13/1 69/32/6 | —/—/26 —/—/88 | >3 (n = 17) >3 (n = 72) | 1-3,5,6, 8–11,14 | — | 19 |
Adachi [13] | 1993 | 1981-1991 | Japan | TACE (+) TACE (−) | 46 26 | 39/7 21/5 | 55.9 ± 7.71 59.8 ± 5.7 | >20 (n = 24) >20 (n = 15) | — — | —/—/29 —/—/22 | 2.6 ± 0.9 2.1 ± 0.9 | 2-4,6-8,11,14,16 | 1,9,13 | 18 |
Harada [28] | 1996 | 1982-1994 | Japan | TACE (+) TACE (−) | 105 35 | 90/15 30/5 | 57.6 ± 9.7 59.8 ± 9.9 | — — | — — | —/—/69 —/—/24 | >5 (n = 36) >5 (n = 9) | 1,2,4,7-10,12 | — | 19 |
Uchida [29] | 1996 | 1986-1991 | Japan | TACE (+) TACE (−) | 60 68 | 50/10 52/16 | 59.0 ± 9.9 62.0 ± 7.2 | >20 (n = 27) >20 (n = 45) | 37/18/5 45/18/5 | —/—/42 —/—/49 | 3.7 ± 3.1 4.4 ± 3.4 | 2,4-10,14 | 1,3,11,13 | 18 |
Majno [10] | 1997 | 1985-1995 | France | TACE (+) TACE (−) | 49 27 | 44/5 26/1 | 59.2 ± 7.1 60.9 ± 7.8 | 285 ± 1629 129 ± 250 | 43/6/0 17/10/0 | 0/0/49 0/0/27 | 5.05 ± 2.5 3.9 ± 1.8 | 1-3,8,10, 12-14 | 5-7 | 18 |
Di Carlo [11] | 1998 | 1989-1997 | Italy | TACE (+) TACE (−) | 55 45 | 49/6 34/11 | 63.0 ± 6.0 62.0 ± 6.0 | >10 (n = 13) >100 (n = 6) | 48/—/— 36/—/— | 0/0/55 0/0/45 | >3 (n = 32) >3 (n = 31) | 1-3,5,7-12,14,15 | 13 | 18 |
Paye [30] | 1998 | 1986-1992 | France | TACE (+) TACE (−) | 24 24 | 21/3 17/7 | 57 ± 2 54 ± 3 | 2560 (2–46000) 4229 (2–73000) | 22/2 22/2 | 1/—/13 1/—/13 | 7.8 ± 1 7.3 ± 1 | 1-3,5-10,12-14,16 | — | 17 |
Lu [31] | 1999 | 1988-1994 | China, Japan | TACE (+) TACE (−) | 44 76 | 36/8 57/19 | 51.5 54.5 | — — | 31/13/0 61/15/0 | —/—/28 —/—/44 | 7.3 7.6 | 2,5,6,8,9,11,14 | 1 | 20 |
Ochiai [32] | 2003 | 1978-1994 | Japan | TACE (+) TACE (−) | 100 48 | 78/22 43/5 | 59.6 ± 8 58.9 ± 8.7 | >400 (n = 74) >400 (n = 30) | — — | —/—/— —/—/— | 4.4 ± 3.3 4.4 ± 3.1 | 1-4,6,7,9, 10,12-15 | — | 20 |
Sugo [33] | 2003 | 1997-2000 | Japan | TACE (+) TACE (−) | 146 81 | 122/24 67/14 | 57.6 ± 9.4 60.5 ± 9 | — — | 118/27/1 74/6/1 | —/—/116 —/—/58 | 4.5 ± 3.0 4.8 ± 3.9 | 2,5,8,9 | 1 | 18 |
Sasaki [34] | 2006 | 1982-2003 | Japan | TACE (+) TACE (−) | 109 126 | 85/24 97/29 | >65 (n = 38) >65 (n = 68) | >100 (n = 40) >100 (n = 49) | — — | —/—/76 —/—/61 | ≥5 (n = 27) ≥5 (n = 47) | 2-4,7,9,11, 12 | 1,8 | 20 |
Chen [35] | 2007 | 1990-2004 | China | TACE (+) TACE (−) | 89 157 | 71/18 136/21 | 45.5 ± 6.3 48.6 ± 5.7 | 2838 ± 1721 2335 ± 1088 | 78/11/0 142/15/0 | —/—/15 —/—/25 | 9.5 ± 2.6 9.9 ± 3.1 | 1-3,6-10,12,13,16 | — | 20 |
Choi [36] | 2007 | 1998-2005 | Korea | TACE (+) TACE (−) | 120 153 | 93/27 117/36 | 52.4 ± 9.6 52.4 ± 10.4 | 8094 ± 68967 2292 ± 7444 | 117/0/0 150/2/0 | —/—/56 —/—/75 | >5 (n = 44) >5 (n = 50) | 1-6,8-10,12-14 | 7 | 19 |
Kim [37] | 2008 | 1995-2000 | Korea | TACE (+) TACE (−) | 97 237 | 80/17 194/43 | 48.8 ± 9.2 51.7 ± 10.2 | >1000 (n = 70) >1000 (n = 31) | 97 237 | —/—/77 —/—/182 | >5 (n = 49) >5 (n = 101) | 1-3,5-10,12,14 | 16 | 19 |
Lee [38] | 2009 | 2000-2006 | Taiwan | TACE (+) TACE (−) | 114 236 | 89/25 173/63 | 57.9 ± 11.3 57.8 ± 11.7 | 2265.88 ± 8438.55 1862.52 ± 1388.63 | 110/4/0 232/4/0 | —/—/79 —/—/152 | 4.3 ± 3.1 3.9 ± 2.7 | 1-3,5,7-10, 12,15 | 11 | 18 |
Kang [39] | 2010 | 1997-2007 | Korea | TACE (+) TACE (−) | 32 64 | 25/7 51/13 | 52.4 ± 9.8 54.0 ± 10.8 | 9584.4 ± 26238.5 5100.9 ± 24773.9 | 30/2/0 64/0/0 | —/—/— —/—/— | 4.3 ± 2.5 4.5 ± 3.2 | 1-3,5,6,9,10,15 | — | 20 |
Yamashita [40] | 2012 | 1995-2008 | Japan | TACE (+) TACE (−) | 42 95 | 36/7 77/18 | 58 ± 12 64 ± 9 | 1527 ± 4415 1125 ± 4713 | 31/—/— 88/—/— | —/—/7 —/—/26 | 9.1 ± 3.2 7.9 ± 3.0 | 2-4,7-11 | 1,5,6 | 20 |