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Table 1 Summary of MDR1 association studies

From: MDR1polymorphisms are associated with inflammatory bowel disease in a cohort of Croatian IBD patients

Author

No of cases

Tested SNP

Population

Results

Schwab et al.

149 UC

C3435T

German

T allele associated with UC (p = 0.049)

126 CD

Croucher et al.

307 UC

C3435T

German & British

No association

562 CD

Brant et al.

119 UC

C3435T G2677T

USA

G2677 associated with IBD (p = 0.003)

409 CD

Glas et al.

123 UC

C3435T

German

No association

135 CD

Potocnik et al.

144 UC

Multiple intron, exon and promoter polymorphisms

Slovenian

2677T associated with UC (p = 0.02); Risk and protective haplotypes identified for UC and CD

139 CD

Gazzouli et al.

85 UC

C3435T

Greece*

No association

120 CD

Ho et al.

335 UC

C3435T

Scottish

3435T associated with UC (p = 0.02); 3435T associated with extensive colitis (p = 0.003)

268 CD

G2677T

Onnie et al.

580 UC

C3435T

British

2677T associated with UC (p = 0.03)

828 CD

G2677T

Urcelay et al.

330 UC

C3435T

Spanish*

C3435T CC genotype associated with CD (p = 0.007)

321 CD

G2677T

Oostenbrug et al.

224 UC

C3435T

Dutch

No association

533 CD

Lal et al.

112 UC

C3435T

Canadian

3435T allele associated with CD (p = 0.02)

247 CD

Fiedler et al.

144 UC

C3435T

German

No association

244 CD

G2677T

Fischer et al.

149 UC

C3435T

Hungarian

No association

265 CD

G2677T

Ardizzone et al.

97 UC

C3435T

Italian

No association

211 CD

G2677T

Huebner et al.

401 UC

G2677T

New Zealand

G2677T protective for UC (p = 0.02)

483 CD

  1. * Data not in Hardy-Weinberg equilibrium.