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Table 4 Use of normal cut-off values of serum tumor markers for gastric cancer diagnosis

From: Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer

 

AFP

CEA

CA125

CA19-9

Combination

Normal boundary value

≤7 ng/mL

≤6.5 ng/mL

≤35 U/mL

≤27 U/mL

-

AUC (95% CI)

0.519

0.583

0.553

0.585

0.667

(0.459~

(0.523~

(0.493~

(0.525~

(0.609~0.726)

0.579)

0.643)

0.614)

0.645)

 

Sensitivity (%)

4.7

17.4

14.1

20.8

40.3

Specificity (%)

99.1

99.1

96.6

96.2

93.2

Accuracy (%)

62.5

67.4

64.6

66.9

72.7

Positive/Negative predictive value (%)

77.8/62.1

92.9/65.4

72.4/63.9

77.5/65.7

78.9/71.1

Positive/negative likelihood ratio

5.52/0.96

20.5/0.83

4.14/0.89

5.43/0.82

5.91/0.64