Table 2 Effectiveness for acute pancreatitis with protease inhibitors
Outcomes | No. of studies | Pooled risk difference | NNT | Heterogeneity | Statistical method by effect model | Quality of a body of evidence | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Value | 95%CI | Value | 95%CI | I2value(%) | ||||||
Lower | Upper | NNTB | NNTH | |||||||
Death | 17 | -0.02 | -0.05 | 0.01 | 74.8 |  | NNTH 62.4 to ∞ to NNTB 23.4 | 0 | M-H | low |
High quality studies | 6 | -0.02 | -0.06 | 0.02 |  | 624.6 | NNTH 24.6 to ∞ to NNTB 26.7 | 34.1 | M-H | |
Aprotinin | 11 | -0.01 | -0.05 | 0.02 | 89.3 |  | NNTH 38.8 to ∞ to NNTB 20.8 | 0 | M-H | |
Gabexate mesilate | 6 | -0.02 | -0.07 | 0.03 | 54.3 |  | NNTH 33.3 to ∞ to NNTB 14.9 | 31.1 | M-H | |
Daily dosage >900 mg of GM | 5 | -0.02 | -0.09 | 0.04 | 55.2 |  | NNTH 8.3 to ∞ to NNTB 14.C | 47.0 | M-H | |
Daily dosage >1500 mg of GM | 2 | -0.09 | -0.33 | 0.15 | 33.6 |  | NNTH 17.8 to ∞ to NNTB 8.6 | 79.0 | D-L | |
Mild pancreatitis | 7 | 0.00 | -0.03 | 0.04 |  | 177.5 | NNTH 24.5 to ∞ to NNTB 33.9 | 0 | M-H | |
Moderate to severe pancreatitis | 10 | -0.03 | -0.07 | 0.01 |  | 1604 | NNTH 23.0 to ∞ to NNTB 23.7 | 19.7 | M-H | |
Severe pancreatitis | 2 | -0.19 | -031 | -0.08 | 5.2 | Â | 3.2 to 12.7 | 0 | M-H | |
With sponsor | 9 | -0.02 | -0.06 | 0.02 | 67.0 |  | NNTH 43.0 to ∞ to NNTB 18.8 | 15.0 | M-H | |
Without sponsor | 8 | -0.02 | -0.06 | 0.03 | 68.4 |  | NNTH 31.9 to ∞ to NNTB 16.5 | 0 | M-H | |
Abdominal pain | 2 | -0.26 | -0.40 | -0.13 | 3.9 | 2.5 to 9.6 | 85.0 | D-L | Â | very low |
High quality study | 1 | -0.14 | -0.32 | 0.03 | 6.9 |  | NNTH 30.1 to ∞ to NNTB 3.1 | Uncalculatable | M-H | |
Pseudocyst formation | 5 | -0.00 | -0.05 | 0.03 | 298.6 |  | NNTH 27.3 to ∞ to NNTB 23.1 | 0 | M-H | low |
Intra-abdominal abscess formation | 4 | -0.01 | -0.04 | 0.02 | 113.2 |  | NNTH 65.3 to ∞ to NNTB 30.3 | 0 | M-H | low |
Surgical intervention | 3 | -0.08 | -0.17 | -0.00 | 11.8 | Â | 6.0 to 443.8 | 60.5 | D0L | very low |
High quality study | 1 | 0.00 | -0.10 | 0.11 |  | 225.8 | NNTH 8.9 to ∞ to NNTB 9.7 | Uncalculatable | M-H | |
Bowel obstruction | 3 | -0.06 | -0.12 | -0.00 | 6.3 | Â | 4.0 to 14.5 | 58.8 | D-L | very low |
High quality study | 1 | -0.03 | -0.08 | 0.02 | 33.9 |  | NNTH 44.2 to ∞ to NNTB 12.3 | Uncalculatable | M-H | |
Any major complications | 5 | -0.01 | -0.08 | 0.06 | 76.4 |  | NNTH 15.7 to ∞ to NNTB 11.1 | 0 | M-H | low |