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Table 3 Clinicopathological features, H. pylori and EBV infection in gastric tumors

From: Occurrence of Helicobacter pyloriand Epstein-Barr virus infection in endoscopic and gastric cancer patients from Northern Brazil

Variable

H. pylori

CagA

EBV

Negative

Positive

p-value

Negativec

Positive

p-value

Negative

Positive

p-value

Age (Median ± IQR)

57 ± 25

64 ± 16.75

0.027*

57 ± 22

64.5 ± 16.5

0.027*

63 ± 20

67 ± 21.5

0.192

Gender [N(%)]

         

Female

9 (22.5)

31 (77.5)

0.023*a

15 (37.5)

25 (62.5)

0.307a

39 (97.5)

1 (2.5)

0.115a

Male

6 (7.1)

79 (92.9)

 

26 (30.6)

59 (69.4)

 

74 (87.1)

11 (12.9)

 

Tumor location [N(%)]

         

Non-cardia

12 (16.4)

61 (83.6)

0.080b

26 (35.6)

47 (64.4)

0.519b

67 (91.8)

6 (8.2)

0.592b

Cardia

3 (5.8)

49 (94.2)

 

15 (28.8)

37 (71.2)

 

46 (88.5)

6 (11.5)

 

Histological subtype [N(%)]

         

Intestinal-type

6 (8.5)

65 (91.5)

0.247b

25 (46.3)

29 (53.7)

0.012*b

63(88.7)

8 (11.3)

0.650b

Diffuse-type

9 (16.7)

45 (83.3)

 

16 (22.5)

55 (77.5)

 

50 (92.6

4 (7.4)

 

Stage [N(%)]

         

Early

7 (15.9)

37 (84.1)

0.680b

25 (56.8)

19 (43.2)

0.000*b

41 (93.2)

3 (6.8)

0.999b

Advanced

6 (8.3)

66 (91.7)

 

14 (19.4)

58 (80.6)

 

64 (88.9)

8 (11.1)

 

Tumor invasion [N(%)]

         

T1/T2

4 (13.3)

26 (86.7)

0.453b

13 (43.3)

17 (56.7)

0.616b

29 (96.7)

1 (3.3)

0.560b

T3/T4

11 (11.6)

84 (88.4)

 

28 (29.5)

67 (70.5)

 

84 (88.4)

11 (11.6)

 

Lymph node metastasis [N(%)]

         

Absent

3 (25)

9 (75.0)

0.193b

8 (66.7)

4 (33.3)

0.024*b

12 (100)

0(0)

0.999b

Present

12 (10.6)

101 (89.4)

 

33 (29.2)

80 (70.8)

 

101 (89.4)

12 (10.6)

 

Distant metastasis [N(%)]

         

Absent

11 (16.7)

55 (83.3)

0.136b

30 (45.5)

36 (54.5)

0.005*b

62 (93.9)

4 (6.1)

0.258b

Present

4 (6.8)

55 (93.2)

 

11 (18.6)

48 (81.4)

 

51 (86.4)

8 (13.6)

 

EBV infection [N(%)]

         

Absent

15 (13.3)

98 (86.7)

0.998b

39 (34.5)

74 (65.5)

0.358b

   

Present

0 (0)

12 (100)

 

2 (16.7)

10 (83.3)

    
  1. *Significant difference between groups, p < 0.05. ap value after adjustment for age; bp value after adjustment for age and gender; cNegative samples for H. pylori and samples with H. pylori infection but without CagA virulence factor; EBV: Epstein-Barr virus; IQR: interquartile range.