Figure 1

Study design. Patients were assigned to four of five treatments by being randomized (R) to one of the following treatment sequences: EABC (n = 2), ABCE (n = 3), BCED (n = 3), CEDB (n = 3), EDBA (n = 3), DABE (n = 3), ABEC (n = 2), BECD (n = 2), ECAD (n = 3) or CADE (n = 3), where A, B, C and D correspond to lesogaberan 30, 90, 120 and 240 mg, respectively, and E corresponds to placebo. The randomization was performed in blocks of consecutive patient numbers.