Parameter | Lesogaberan dose (mg) | Geometric mean | Coefficient of variation (%) |
---|---|---|---|
AUC (0–24 h) , μmol · h/l | 30 | 5.25 | 46.4 |
90 | 17.3 | 31.5 | |
120 | 22.2 | 44.8 | |
240 | 46.9 | 50.0 | |
C max morning, μmol/l | 30 | 0.35 | 59.2 |
90 | 1.30 | 38.2 | |
120 | 1.48 | 53.5 | |
240 | 3.31 | 69.3 | |
C max evening, μmol/l | 30 | 0.42 | 59.5 |
90 | 1.68 | 43.8 | |
120 | 2.21 | 50.3 | |
240 | 4.18 | 36.8 | |
t max morning, h | 30 | 1.7 | 25.2 |
90 | 1.7 | 26.7 | |
120 | 1.9 | 53.1 | |
240 | 1.7 | 27.6 | |
t max evening, h | 30 | 2.2 | 56.4 |
90 | 1.9 | 47.1 | |
120 | 1.9 | 35.9 | |
240 | 2.6 | 73.4 |