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Table 2 Pharmacokinetic measures in patients during dosing with lesogaberan 30 (n = 18), 90 (n = 20), 120 (n = 21) and 240 mg (n = 19)

From: Dose-dependent effects of lesogaberan on reflux measures in patients with refractory gastroesophageal reflux disease: a randomized, placebo-controlled study

Parameter

Lesogaberan dose (mg)

Geometric mean

Coefficient of variation (%)

AUC (0–24 h) , μmol · h/l

30

5.25

46.4

 

90

17.3

31.5

 

120

22.2

44.8

 

240

46.9

50.0

C max morning, μmol/l

30

0.35

59.2

 

90

1.30

38.2

 

120

1.48

53.5

 

240

3.31

69.3

C max evening, μmol/l

30

0.42

59.5

 

90

1.68

43.8

 

120

2.21

50.3

 

240

4.18

36.8

t max morning, h

30

1.7

25.2

 

90

1.7

26.7

 

120

1.9

53.1

 

240

1.7

27.6

t max evening, h

30

2.2

56.4

 

90

1.9

47.1

 

120

1.9

35.9

 

240

2.6

73.4

  1. AUC, area under the curve; Cmax, peak concentration; tmax, time to reach peak concentration.