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Table 1 Group definitions and demographics of the cases studied.

From: Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients

 

Group A

Group B

Group C

 

Positive group with A-GVHD by skin biopsy*.

Cases of BMT. Underlying indications for BMT are shown as the foot notes of this table**.

With diarrhea and without identifiable infectious etiology and history of drugs like NSAIDs, steroids.

Negative control group I.

Without any transplantation and immunosupresion.

With GI symptoms like diarrhea, guaiac positive stool.

Negative control group II.

With kidney transplantation***.

With GI symptoms like diarrhea, guaiac positive stool.

Age

   

   Mean

41.6 years

51.5 years

60.3 years

SD

9.2

12.5

8

Range

19 to 59 years

20 to 77 years

46 to 75 years

Sex

   

   Males

25

13

14

Females

19

14

7

Total

44*

27

21

  1. *The splitting of total cases according to the grading of cutaneous A-GVHD: Grade I- 20, Grade II- 13, Grade III- 5, Grade IV- 6. **The diagnoses for which BMT was done includes: Hodgkin's Lymphoma (3), Non-Hodgkin's Lymphoma (4), T-cell Lymphoblastic Lymphoma (5), IgG Multiple myeloma (3), Plasma cell leukemia (1), Chronic Myelogenous Leukemia (17), Chronic myelomonocytic Leukemia (2), Myelodysplastic syndrome (1), and Others (8). All cases received the same conditioning regimen (cyclophosphamide [Cytoxan], cytosine arabinoside, and total body irradiation). The type of A-GVHD prophylaxis used was post-transplatation cyclosporin A. ***The duration of kidney transplantation ranged from 8 to 64 months (mean 28 months).