Synergic effect of chronic hepatitis C infection and beta thalassemia major with marked hepatic iron overload on liver fibrosis: a retrospective cross-sectional study

Table 1 Demographic and histopathologic findings in the three groups

	Group 1	Group 2	Group 3	P value
				Group 1 vs. 2	Group 1 vs. 3
Age(years)*	21.55+/-4.74	29.7+/-9.16	18.7+/-4.45	*0.001*	0.057
Sex (M/F)	10/10	13/7	10/10	0.33	1
Modified Stage ^‡	3 (1–6)	2 (0–6)	2 (1–4)	*0.02*	*0.01*
Modified HAI grade ^‡	5 (1–8)	6 (2–11)	2 (0–6)	0.36	*0.001*
Periportal inflammation^‡	1.5 (0–3)	2 (0–4)	0 (0–2)	0.77	*0.004*
Confluent Necrosis^‡	0 (0–1)	0 (0–2)	0 (0–1)	0.13	0.091
Focal Necrosis^‡	1 (0–2)	2 (1–2)	1 (0–2)	0.10	0.45
Portal Inflammation^‡	2 (0–3)	2 (1–4)	1 (0–2)	0.87	*0.002*
Iron Score ^‡	3 (2–4)	0 (0–1)	4 (2–4)	*0.000*	*0.024*
Steatosis (%)	10	20	0	0.66	0.48

* mean+/-standard deviation ^‡Median (minimum-maximum) Group 1: Patients with beta thalassemia major and chronic HCV infection Group 2: Patients with chronic HCV infection Group 3: Patients with beta thalassemia major

ISSN: 1471-230X