Figure 4
From: Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen
Histological evaluation after repeated induction of pancreatitis in transgenic mice and controls: R122H transgenic animals and controls were sacrificed without treatment (a, b) or after repetitive induction of experimental pancreatitis (c, d) R122H transgenic mice (grey) and controls (white) were left untreated or were treated with repetitive inductions of pancreatitis in a minimum of 7 animals per group. Pancreata of the animals were histologically evaluated for the grade of diffuse infiltration (e). R122H transgenic mice (d) showed significantly higher grade of diffuse inflammatory infiltration than control animals (c). Statistical analysis using the Mann-Whitney-Test with p < 0.05 was considered significant.