Figure 2
From: Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
Impaired resolution of centrilobular injury in mice lacking receptor-free uPA. Histological liver sections 2 days after CCl4 show similar features of centrilobular necrosis (arrows) in mice of all genotypes. While livers from wild type (WT), uPAR°, and uPAR°/tPA° show resolution of the centrilobular injury by day 7, uPA° livers continue to display the injury at 7 and 14 days after CCl4 despite the presence of uPAR (Magnification 200×)