Effects of urodilatin on natriuresis in cirrhosis patients with sodium retention

BMC Gastroenterology

Table 1 The basal characteristics of the 6 patients included in the statistical analysis.

	No. 1	No. 2	No. 3	No. 4	No. 5	No. 6
[unit/reference interval]	Male	Male	Female	Male	Male	Female
Total Plasma Bilirubin [< 22 micromol/L]	33	549	35	33	17	38
Plasma Albumin [551–725 micromol/L]	366	445	330	506	272	294
PP [0.80–1.20 arbitrary units]	0.55	0.20	0.30	0.66	0.42	0.39
Ascites	yes	yes	yes	yes	yes	yes
Encephalopathy	no	no	no	no	no	no
MELD score [5–15 points]	6	27	9	6	6	9
Plasma Sodium [136–146 mmol/L]	132	134	140	135	125	132
Plasma Creatinine [55–120 micromol/L]	105	50	62	85	52	58
Urine Sodium/24 hours [mmol/24 h]	10	35	27	48	35	31
UNa (baseline) [μmol/min]	URO 3.1 Pl. 6.7	URO 28.1 Pl. 14.8	URO 36.7 Pl. 37.0	URO 22.5 Pl. 41.4	URO 44.0 Pl. 40.0	URO 18.7 Pl. 34,7
V (baseline) [mL/min]	URO 0.44 Pl. 1.04	URO 0.35 Pl. 0.44	URO 1.20 Pl. 1.77	URO 0.74 Pl. 0.90	URO 1.18 Pl. 1.65	URO 0.93 Pl. 1.93
Serum Renin [10–70 mIU/L]	273	527	19	371	104	545
Serum Angiotensin II [10–30 pmol/L]	97	100	6	42	33
Serum Aldosterone [40–500 pmol/L]	5363	1419	287	171	306	1768
Systemic Blood Pressure [mmHg]	95/60	112/65	100/60	112/65	105/80	100/65
Furosemide [mg/24 hours]	80	40	40	120	80	80
Spironolactone [mg/24 hours]	200	200	200	200	200	200

URO = urodilatin. Pl. = placebo. UNa = urine sodium excretion rate. V = urine flow rate. PP = prothrombin time. MELD = Model of End-stage Liver Disease.

ISSN: 1471-230X