Figure 4From: Epigenetic mechanisms involved in differential MDR1mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy Comparison of Pgp expression and function in gastric and colon cancer cell lines. (A) Comparative sensitivity of Colo320HSR (colon, highest), SNU-668 (gastric, highest) and SNU-C5 (colon, no expression) to paclitaxel; (B) Effects of Pgp inhibitors on the sensitivity of Colo320HSR, SNU-668 and SNU-C5 to paclitaxel (IC10 concentration; 50 μM, 0.3 nM and 0.5 nM, respectively). Sensitivity to paclitaxel was determined using MTT assay in the presence or absence of the Pgp inhibitors (cyclosporin A, verapamil and PSC833 of 0.8 μM each). *, P <0.05 versus the control.Back to article page