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Table 1 Small intestinal histopathology classifications – a comparison

From: Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers

Classification used in this project

Normal

Inflammation

Villous atrophy

Marsh Classification*

Type 0

Type 1

Type 2

Type 3a

Type 3b

Type 3c

Marsh

Description

Pre-infitrative

Infiltrative

Infiltrative-hyperplastic

Flat destructive

Corazza et al [5]

-

Grade A

Grade B1

Grade B2

SnoMed Codes

M0010,

M0011

M40000, M41000,

M42000, M43000,

M47000, M47170

M58,

D6218,

M58005

M58,

D6218,

M58006

M58,

D6218,

M58007

KVAST/Alexander classification

I

Normal

II

Intraepithelial lymphocytosis (IEL)#

III

Partial VA

IV

Subtotal VA

IV

Total VA

Characteristics

      

Villous atrophy

-

-

-

+

++

++

IEL#

-

+

+

+

+

+

Crypt hyperplasia

-

-

+

+

++

++

  1. *We have not included Marsh type 4 in this classification since such lesions are very rare [9] and cannot be identified through SnoMed Codes.
  2. # Increased intraepithelial lymphocyte count (often >30/100 epithelial cells).