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Table 1 Effects of flovoksamine (FLU) and ranitidine (RAN) on indomethacin (IND) induced ulcers in rats.

From: Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue

Drugs

Dose

(mg/kg)

Number of animals

Ulcer area (mm2)

Antiulcer effect (%)

P

FLU

25

   

< 0.05

+

 

6

15.3 ± 1.5

48.5

 

IND

25

    

FLU

50

   

< 0.02

+

 

6

9.7 ± 0.9

67.5

 

IND

25

    

FLU

100

   

< 0.01

+

 

6

5.3 ± 0.4

82.1

 

IND

25

    

FLU

200

   

< 0.001

+

 

6

1.2 ± 0.02

96.1

 

IND

25

    

RAN

50

   

< 0.001

+

 

6

4.0 ± 0.6

86.5

 

IND

25

    

Indomethacin (Control)

25

6

29.7 ± 2.6

-

-