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Table 2 Effects of fluvoxamine (FLU) alone and ranitidine (RAN) alone on tGSH, NO, MPO, and MDA levels in the stomach tissues of rats.

From: Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue

Drugs

Dose

(mg/kg)

tGSH

MDA

NO

MPO

FLU

25

14.9 ± 0.6

2.1 ± 0.3

80.4 ± 6.3

1.0 ± 0.02

FLU

50

15.1 ± 0.3*

1.8 ± 0.2*

95.2 ± 4.5*

0.8 ± 0.04*

FLU

100

17.1 ± 0.8*

1.7 ± 0.3*

99.7 ± 5.7*

0.5 ± 0.03*

FLU

200

18.3 ± 0.6*

1.6 ± 0.2*

105.1 ± 5.2*

0.4 ± 0.01*

RAN

50

15.8 ± 0.4*

2.1 ± 0.5*

96.8 ± 4.7*

0.6 ± 0.03*

Intact (Control)

-

12.7 ± 0.2

2.3 ± 0.4

83.4 ± 3.6

1.1 ± 0.05

  1. *Significant at p < 0.05 when compared to intact control.