Figure 1

Gastric acid-evoked expression of c-Fos in the nucleus tractus solitarii (NTS) and area postrema (AP) in a rat treated with vehicle (A) and another rat treated with lafutidine (B). Lafutidine (30 mg/kg) or its vehicle (0.5% carboxymethyl cellulose) was administered perorally 30 min before the stomach was exposed to an exogenous acid load (0.25 M HCl). Two hours post-HCl c-Fos-positive cells in the brainstem were visualized by immunocytochemistry.