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Table 5 Multivariate logistic regression analysis of variables associated with decrease sustained virological response rates to alpha interferon plus ribavirin treatment in chronic HCV patients (N = 400).

From: A study of best positive predictors for sustained virologic response to interferon alpha plus ribavirin therapy in naive chronic hepatitis C patients

Variable

SVR/Total No. of treated patients

Adjusted OR*

95% CIψ

Age, years

   

> 40

58/149

1.5

0.9–2.4

≤ 40

144/251

  

Ethnic group

   

East (Punjab)

136/299

1.6

1.0–3.2

North-west (NWFP)

54/78

  

Pre-treatment viral load

   

> 0.2 MIU/mL

29/109

2.2

1.8–4.2

< 0.2 MIU/mL

173/291

  

Rapid virological response

   

Achieved

139/186

2.6

1.9–3.7

Not achieved

63/214

  

HCV genotype

   

1, 4, 5, 6 or mixed with these genotypes

21/85

2.4

1.7–3.5

2, 3 or mixed with these genotypes

181/315

  

Cirrhosis

   

Present

0/16

--

CI cannot be

Absent

23/41

 

calculated

  1. *OR, Odd ratio
  2. ψCI, Confidence interval
  3. SVR-Sustained virologic response, defined as undetectable HCV RNA 24 weeks after end of anti-viral treatment.
  4. The number of participants does not add up to 400 for one variable due to it being not applicable.