The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center

BMC Gastroenterology

Table 1 Clinical presentation, histology, genetics and associated disorders in patients with seronegative celiac disease

Pts	Gender	Age at diagnosis	Clinical phenotype	HLA-typing	Duodenal biopsy		Anti-TG2	AGA	Associated disorders
Pts	Gender	Age at diagnosis	Clinical phenotype	HLA-typing	Untreated	After GFD	EmA DGP	AGA	Associated disorders
#1	Male	58	Classical	DQ2+	3c	1	Neg	IgG + ve	Autoimmune thyroiditis
#2	Female	34	Classical	DQ2+	3a	1	Neg	IgG + ve	PBC
#3	Female	37	Classical	DQ2+	3c	1	Neg	Neg	None
#4	Female	75	Classical	DQ2+	3c	1	Neg	Neg	None
#5	Female	45	Classical	DQ2+	3a	1	Neg	Neg	None
#6	Female	55	Classical	DQ2+	3c	1	Neg	IgG + ve	Gluten ataxia
#7	Male	61	Classical	DQ8+	3b	1	Neg	Neg	Peripheral neuropathy
#8	Female	48	Classical	DQ2+	3c	1	Neg	Neg	None
#9	Female	49	Classical	DQ2+	3a	1	Neg	IgG + ve; IgA + ve	Autoimmune gastritis
#10	Female	30	Classical	DQ2+	3b	1	Neg	Neg	None
#11	Female	63	Classical	DQ2+	3c	1	Neg	Neg	None

Note: Anti-TG2: tissue transglutaminase antibodies, EmA: endomysial antibodies, DGP: deamidated gliadin antibodies, AGA: gliadin antibodies, GFD; gluten-free diet, PBC; primary biliary cirrhosis; duodenal biopsy scored according to Marsh-Oberhüber classification: "3a", partial; "3b", subtotal; "3c", total villous atrophy; "1" indicates increased intraepithelial lymphocytes.

ISSN: 1471-230X