Figure 7

Liver regeneration as evaluated by mitotic index (HE sections) in 60-70% partially hepatectomized rats and SB-269970. Time course of liver regeneration as evaluated by mitotic index (HE sections) in 60-70% partially hepatectomized rats having received intraperitoneally saline (group A) or SB-269970 hydrochloride (2 mg/kg bodyweight) 2 h prior to partial hepatectomy (group B) or SB-269970 hydrochloride (2 mg/kg bodyweight) 16 h after partial hepatectomy (group C) or SB-269970 hydrochloride (2 mg/kg bodyweight) 2 h prior and 16 h after partial hepatectomy (group D). Mitotic index was expressed as mean number of mitoses/high-power field (HPF). Results represent the findings from at least five rats: killed at 8, 18, 20, 24, 32, 40, 60 h and 72 h (groups A, B and D) and at 18, 20, 24, 32, 40, 48, 60 and 72 h (group C). Values are expressed as means ± SE. Mitotic index group A vs group C and D; P < 0.001: 24–32 and 60 h; P < 0.01: 40 h. Mitotic index group A vs groups B, C and D; P < 0.01: 18 and 20 h. Mitotic index group A vs group C; P < 0.01: 48 h.