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Table 6 Pooled analysis of studies exploring the role of TLR4 Thr399Ile in IBD

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Study

Sample size

Cases (Events/Total)

Controls (Events/Total)

Odds

95% CI

P value

Torok et al. 2004 [ [33]]

IBD: 200

38/400

12/290

2.432

1.24 to 4.74

 

HC: 145

Gazouli et al. 2005 [ [36]]

IBD: 205

4/410

2/200

0.975

0.17 to 5.37

 

HC: 100

Oostenbrug et al. 2005 [ [37]]

IBD: 721

93/1442

29/598

1.353

0.88 to 2.07

 

HC: 299

Zouiten-Mekki et al. 2009 [ [40]]

IBD: 120

15/240

8/160

1.267

0.52 to 3.06

 

HC: 80

Browning et al. 2007 [ [42]]

IBD: 794

106/1588

46/832

1.222

0.85 to 1.74

 

HC: 416

De Ridder et al. 2007 [ [23]]

IBD: 707

106/1414

22/488

1.717

1.07 to 2.75

 

HC: 244

Rigoli et al. 2008 [ [45]]

IBD: 178

12/356

6/206

1.163

0.43 to 3.14

 

HC: 103

Manolakis et al. 2013 [ [46]]

IBD: 350

61/700

33/548

1.490

0.96 to 2.31

 

HC: 274

Our study 2014

IBD: 117

10/234

3/224

3.289

0.89 to 12.11

 

HC: 112

Total (fixed effects)

 

445/6784

161/3546

1.479

1.22 to 1.82

0.0001

Total (random effects)

 

445/6784

161/3546

1.465

1.21 to 1.80