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Table 9 Genotype-phenotype correlations in patients with Crohn’s disease

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Parameter

N

Asp299gly (%)

P value

Chi-square test

Thr399Ile (%)

P value

Chi-square test

AA

AG

GG

CC

CT

TT

  

Age of onset

83

   

0.48

1.45

   

0.59

1.05

<17 years

10

10 (100.0)

-

   

10 (100.0)

-

   

17-40

63

55 (87.3.)

8 (12.7)

   

57 (90.5)

6 (9.5)

   

>40 years

10

9 (90.0)

1 (10.0)

   

9 (90.0)

1 (10.0)

   

Sex

83

   

0.35

0.87

   

0.17

1.92

Woman

25

24 (96.0)

1 (4.0)

   

25 (100.0)

-

   

Man

58

50 (86.2)

8 (13.8)

   

51 (87.9)

7 (12.1)

   

Type

83

   

0.54

2.14

   

0.36

3.23

Fistulizing

35

31 (88.6)

4 (11.4)

   

33 (94.3)

2 (5.7)

   

Non fistulizing non stenosing

24

20 (83.3)

4 (16.7)

   

20 (83.3)

(16.7)

   

Stenosing

17

16 (94.1)

1 (5.9)

   

16 (94.1)

1 (5.9)

   

Fistulizing stenosing

7

7 (100.0)

-

   

7 (100.0)

-

   

Localization

83

   

0.80

1.67

   

0.94

0.82

L1

30

26 (86.7)

4 (13.3)

   

27 (90.0)

3 (10.0)

   

L2

20

17 (85.0)

3 (5.0)

   

18 (90.0)

2 (10.0)

   

L3

26

24 (92.3)

2 ()

   

24 (92.3)

2 (7.7)

   

L4

3

3 (100.0)

-

   

3 (100.0)

-

   

L4 + L2

4

4 (100.0)

-

   

4 (100.0)

-

   

Smoking

83

   

0.04

4.44

   

0.17

1.92

Presence

33

26 (78.8)

7 (21.2)

   

28 (84.8)

5 (15.2)

   

Absence

50

48 (96.0)

2 (4.0)

   

48 (96)

2 (4.0)

   

SFC

83

   

0.91

0.01

   

0.76

0.09

Presence

4

4 (100.0)

-

   

4 (100.0)

-

   

Absence

79

70 (88.6)

9 (11.4)

   

72 (91.1)

7 (8.9)

   

Appendectomy

83

   

0.84

0.04

   

0.58

0.30

Presence

12

11 (91.7)

1 (8.3)

   

10 (83.3)

2 (16.7)

   

Absence

71

63 (88.7)

8 (11.3)

   

66 (93.0)

5 (7.0)

   

EIM

83

   

0.97

0.001

   

0.97

0.001

Presence

42

38 (90.5)

4 (9.5)

   

39 (92.9)

3 (7.1)

   

Absence

41

36 (87.8)

5 (12.2)

   

37 (95.1)

4 (4.9)

   

Surgery

83

   

0.50

0.45

   

0.45

0.57

Presence

41

38 (92.7)

3 (7.3)

   

39 (95.1)

2 (4.9)

   

Absence

42

36 (85.7)

6 (14.3)

   

37 (88.1)

5 (11.9)

   
  1. SFC: similar familial cases; EIM: extra intestinal manifestations; N: total number; AA: wild type TLR4 Asp299gly, AG: TLR4 Asp299gly heterozygous variant, GG: TLR4 Asp299gly homozygous variant; CC: wild type TLR4 Thr399Ile, CT: TLR4 Thr399Ile heterozygous variant, TT: TLR4 Thr399Ile homozygous variant.