Table 4 Level of significance and odds ratio’s for different variables used in a multivariate logistic regression model predicting sensitivity of a FIT at cut-off of 75 ng/ml for detection of CRC and advanced adenomas
CRC | Advanced adenoma | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Univariate model | Multivariate model | Univariate model | Multivariate model | ||||||
Variable | OR (95% CI) | p-value | OR (95% CI) | p-value | Variable | OR (95% CI) | p-value | OR (95% CI) | p-value |
Sex (ref = female) (N = 69) | 5.77 (1.33-24.95) | 0.02 | 6.16 (1.15-32.92) | 0.03 | Sex (ref = female) (N = 304) | 1.23 (0.75-2.00) | 0.41 | 1.00 (0.57-1.75) | 0.99 |
Age (continuous variable) (N = 69) | 1.01 (0.94-1.08) | 0.89 | 1.00 (0.92-1.08) | 0.96 | Age (continuous variable) (N = 304) | 1.01 (0.98-1.03) | 0.55 | 1.00 (0.98-1.03) | 0.75 |
Location (ref = right-sided) (N = 68) | 4.30 (1.07-17.35) | 0.04 | 4.83 (0.95-24.8) | 0.05 | Location (ref = right-sdided (N = 303) | 1.94 (1.26-2.98) | 0.002 | 1.31 (0.79-2.20) | 0.30 |
T-stage (ref = T1) (N = 55) | 1.57 (0.39-6.32) | 0.53 | 2.19 (0.44-10.80) | 0.34 | AA size (ref = <10 mm) (N = 285) | 5.58 (2.55-12.22) | <0.001 | 5.24 (2.32-11.83) | <0.001 |
Presence of AA (ref = none) (N = 69) | 0.83 (0.09-7.54) | 0.87 | 1.38 (0.09-20.52) | 0.81 | Number of AA (ref = 1) (N = 300) | 4.82 (2.63-8.85) | <0.001 | 4.27 (2.10-8.70) | <0.001 |