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Table 1 Subject characteristics and univariate logistic regression analysis of factors associated with non-adherence (N = 429)

From: A screening instrument to identify ulcerative colitis patients with the high possibility of current non-adherence to aminosalicylate medication based on the Health Belief Model: a cross-sectional study

 

n (%) or Mean ± SD 1

OR 2

95% CI 3

p value

Beliefs about taking aminosalicylates

     

Susceptibility [0-4]

1.5 ± 0.9

1.61

1.28–2.02

<0.01

Severity [0-4]

0.7 ± 1.0

2.22

1.78–2.75

<0.01

Benefits [0-8]

2.5 ± 1.7

1.32

1.17–1.49

<0.01

Barriers [0-48]

21.3 ± 9.9

1.11

1.07–1.13

<0.01

Cues to action [0-12]

4.6 ± 2.7

1.20

1.10–1.30

<0.01

Disease characteristics

     

Duration of UC: Less than 5 years [more than 5 years]

143

(33.4)

1.20

0.76–1.86

0.44

Family history: Absence [presence]

409

(95.3)

0.98

0.37–2.61

0.96

The duration of current remissiona: More than 3 months [less than 3 months]

330

(77.3)

1.57

0.92–2.66

0.09

Disease region by recent colonoscopyb: Rectum [total, left-side]

113

(26.4)

1.54

0.98–2.43

0.06

Medication characteristics

     

Aminosalicylates

     
 

Type of aminosalicylatesc: Mesalazine [salazosulfapyridine]

130

(32.8)

1.02

0.64–1.61

0.94

 

Times of day at which the drugs were taken:

278

(64.8)

1.14

0.74–1.77

0.55

2 times or less [3 times or more]

 

Number of tablets/day: 8 tablets or less [9 tablets or more]

216

(50.3)

1.79

1.18–2.73

<0.01

 

Prescribed dose (g/day)

3.5 ± 0.9

0.75

0.59–0.95

0.02

Current concomitant therapy

     
 

Topical aminosalicylates: Absence [presence]

301

(70.2)

1.11

0.70–1.75

0.66

 

Oral corticosteroids: Absence [presence]

404

(94.2)

2.30

0.77–6.84

0.13

 

Topical corticosteroids: Absence [presence]

395

(92.1)

1.68

0.71–3.97

0.23

 

Thiopurines: Absence [presence]

369

(86.0)

2.32

1.14–4.39

0.02

 

Calcineurin inhibitors: Absence [presence]

410

(95.6)

1.19

0.42–3.37

0.78

 

Leukocyte apheresis: Absence [presence]

421

(98.1)

1.27

0.25–6.36

0.77

 

Biologics: Absence [presence]

403

(93.9)

2.41

0.82–7.16

0.11

Abdominal symptoms

     
 

Stool consistency: Formed [liquid]

375

(87.4)

0.99

0.53–187

0.99

 

Bowel movements/day: 3 times or less [4 times or more]

178

(41.5)

1.22

0.80–1.85

0.36

 

Urgency: Absence [presence]

239

(55.7)

1.21

0.80–1.85

0.37

 

Pain: Absence [presence]

288

(67.1)

0.89

0.58–1.38

0.61

 

Visible bleeding: Absence [presence]

313

(73.0)

1.65

1.003–2.71

0.04

Sociodemographic characteristics

     

Gender: Male [female]

243

(56.6)

0.87

0.58–1.33

0.53

Age

39.9 ± 12.5

0.99

0.97–1.01

0.27

Employment: Full time job, family-operated business [part time job, student, housewife, unemployed]

243

(56.6)

1.32

0.87–2.02

0.19

Marital status: Married [unmarried, divorced, widowed]

251

(41.5)

0.92

0.60–1.41

0.71

Educational level: Junior high school, high school, vocational school, junior college [college or higher]

207

(48.2)

0.93

0.61–1.40

0.71

Living situation: Living alone [living with someone]

68

(15.9)

1.14

0.65–1.98

0.65

Hospital

     
 

Hospital B [A]

239

(55.7)

1.10

0.65–1.85

0.72

 

Hospital C [A]

87

(20.3)

1.72

0.93–3.19

0.10

  1. Information in [brackets] are reference categories.
  2. an = 427, bn = 428, cn = 397 (32 subjects were prescribed two kinds of aminosalicylates and not included in this analysis).
  3. 1SD: standard deviation, 2OR: odds ratio, 3CI: confidence interval.
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BMC Gastroenterology

ISSN: 1471-230X

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