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Table 2 Univariate analysis for overall recurrence-free survival among patients with T3-4a colorectal cancer

From: Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse

 

Colorectal cancer (n = 277)

Rectal cancer (n = 104)

Colon cancer (n = 173)

Variables

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

miR-21 expression (low vs. high)

2.02 (1.18-3.45)

0.010

1.32 (0.62-2.85)

0.474

3.09 (1.41-6.76)

0.005

Age (<65 years vs. ≥65 years)

0.97 (0.57-1.66)

0.920

0.45 (0.20-1.02)

0.055

2.12 (0.95-4.77)

0.068

Tumor type (non-mucinous vs. mucinous)

1.18 (0.37-3.78)

0.783

3.03 (0.70-13.05)

0.138

0.67 (0.09-4.94)

0.693

Differentiation (well or moderately vs. poorly)

2.56 (1.09-6.00)

0.031

4.57 (1.33-15.67)

0.016

2.06 (0.60-7.00)

0.249

pT (T3 vs. T4a)

2.68 (1.51-4.76)

0.0005

3.97 (1.73-9.12)

0.001

2.30 (1.00-5.30)

0.044

Lymph node metastasis (absent vs. present)

3.69 (1.98-6.87)

0.00001

6.65 (2.30-19.22)

0.0004

2.24 (1.00-5.02)

0.045

CEA (<5 ng/dL vs. ≥5 ng/dL)

2.24 (1.26-3.99)

0.006

2.26 (1.02-5.05)

0.046

2.23 (0.97-5.15)

0.060

Adjuvant therapy (no vs. yes)

4.19 (0.58-30.35)

0.156

NA

NA

3.23 (0.44-23.98)

0.252

  1. HR, hazard ratio; CI, confidence interval; NA, not available.