From: Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis
No. | SPINK1* 14/221 (6.3 %) | OR * (95 % CI) | P value | CFTR** 5/221 (2.3 %) | OR (95 % CI) | P value | CTRC** 4/221 (1.8 %) | OR (95 % CI) | P value | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Severity of the course | ||||||||||||
Mild AP | 144 | 6 (4.2 %) | 2.05 (0.85-5.1) | P < 0.005 | 4 (2.8 %) | 0.59 (0.16- 1.80) | NS | 2 (1.4 %) | 1.57 (0.29-8.52) | NS | ||
Moderate AP | 39 | 7 (17.9 %) | 8 (10.4 %) | 0 | 2 (1.4 %) | 1,4 % | ||||||
Severe AP | 38 | 1 (2.6 %) | 1 (2.6 %) | 1 (2.6 %) | ||||||||
Etiology of AP | ||||||||||||
Alcohol | 70 | 5 (7.1 %) | 2.33 (0.61- 7.57) | NS | 1 (1.4 %) | 0.37 (0.01-2.55) | NS | 2 (2.9 %) | 2.50 (0.22- 17.84) | NS | ||
Gallstones | 81 | 5 (6.2 %) | 1.99 (0.53- 6.45) | 3 (3.7 %) | 0.98 (0.18- 3.7) | 2 (2.5 %) | 2.15 (0.19-15.33) | |||||
Idiopathic | 63 | 4 (6.3) | 2.05 (0.46- 7.23) | 0 | 0 (0–1.78) | 0 | 0 (0–8.365) | |||||
Cancer | 7 | 0 | 0 (0–23.88) | 1 (14.3 %) | 4.2 (20.09- 39.08) | 0 | 0 (0–85.65) | |||||
Reccurrences of AP | ||||||||||||
Yes | 82 | 5 (6.1 %) | 1.97 (0.52- 6.37) | NS | 1 (1.2 %) | 0.32 (0.01- 2.16) | NS | 2 (2.4 %) | 2.13 (0.19- 15.135) | NS | ||
No | 139 | 9 (6.5 %) | 2.10 (0.75- 5.72) | 4 (2.9 %) | 0.76 (0.18- 2.51) | 2 (1.4 %) | 1.24 (0.111-8.8 | |||||
Control group | 345 | 11 (3.2 %)* | 13 (3.8 %)** | 4 (1.2 %)** |