Fig. 1From: Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteersa Study protocol. Esophageal motor function and gastroesophageal reflux were evaluated after a 7-day administration of acotiamide (300Â mg/day) or no medication using a cross-over protocol. On the day before the last day of administration, determinations of esophageal motor function were performed by high resolution manometry (HRM). After finishing the HRM, 24-hour esophageal multichannel intraluminal impedance and pH testing (MII-pH) were conducted. The 2 trials (with and without acotiamide) were conducted at least 1Â week apart and in random order. b Schedule on the day of HRM and MII-pHBack to article page