Table 3 Results of meta-analysis comparing hepatocellular carcinoma with or without biliary tumor thrombus

Clinicopathological characteristics

 Male

12

317 5806

1.07

0.97, 1.43

0.67

0.69

 Age

9

256 3840

0.01

−1.01, 1.02

0.99

0.01

 Hepatitis B surface antigen

11

297 5150

1.33

0.99, 1.79

0.06

0.35

 Hepatitis C virus antibody

9

243 4274

0.72

0.37, 1.39

0.33

0.03

 Cirrhosis

6

158 3569

0.72

0.51, 1.00

0.05

0.11

 Tumor size

7

177 4028

−0.89

−2.63, 0.85

0.32

<0.001

 Multiple tumor

6

166 3662

1.85

0.76, 4.52

0.18

<0.001

 Tumor capsule absence

7

176 2305

1.26

0.63, 2.51

0.62

0.02

 Intrahepatic metastases

5

109 1710

1.47

0.93, 2.33

0.10

0.40

 Vscular invasion

12

293 5939

4.70

2.90, 7.60

<0.001

0.001

 Poor differentiation

8

227 4003

2.07

1.23, 3.49

0.006

0.05

Long-term outcomes

 1-year overall survival

12

280 4739

0.48

0.31, 0.72

<0.001

0.02

 3-year overall survival

12

280 4739

0.45

0.29, 0.68

<0.001

0.007

 5-year overall survival

10

231 4021

0.31

0.21, 0.64

<0.001

0.02