Effect of coexisting diabetes mellitus and chronic kidney disease on mortality of cirrhotic patients with esophageal variceal bleeding

Table 3 Adjusted Risk for 42-Day and One-Year Mortality Stratified by DM, Chronic Kidney Diseases, and Sex

	42-day mortality						One-year mortality
	Model 1^a			Model 2^b			Model 3^a			Model 4^b
	HR	95 % CI	P value	HR	95 % CI	P value	HR	95 % CI	P value	HR	95 % CI	P value
All patients
Non-DM & CKD	Ref.						Ref.
Only DM	0.72	0.50–1.02	0.062				0.80	0.64–1.02	0.066
Only CKD	1.25	0.62–2.52	0.541				1.07	0.65–1.76	0.801
DM + CKD	1.99	1.03–3.84	0.042				1.84	1.14–2.98	0.012
P for DM × CKD interaction	0.100							0.028
Women
Non-DM & CKD				Ref.						Ref.
Only DM				1.11	0.56–2.21	0.772				0.77	0.49–1.21	0.260
Only CKD				3.40	0.75–15.48	0.113				1.30	0.39–4.28	0.672
DM + CKD				4.03	1.40–11.59	0.010				2.84	1.31–6.14	0.008
Men
Non-DM & CKD				2.00	1.14–3.52	0.016				1.61	1.13–2.29	0.009
Only DM				1.25	0.67–2.32	0.487				1.32	0.90–1.92	0.154
Only CKD				2.02	0.83–4.94	0.123				1.64	0.90–2.98	0.108
DM + CKD				2.93	1.14–7.57	0.026				2.42	1.28–4.57	0.007
P for gender × diseases interaction				0.920						0.559

CI confidence interval, CKD chronic kidney disease, DM diabetes mellitus, HR hazard ratio, Ref reference
^aAdjusted for sex, age, comorbidities, etiology of cirrhosis, complications of cirrhosis, low income and urbanization
^bAdjusted for age, comorbidities, etiology of cirrhosis, complications of cirrhosis, low income and urbanization

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